Circulating Interleukin-6 (but Not Other Immune Mediators) Associates with Criteria for Fried’s Frailty among Very Old Adults
Table 1
Anthropometric and metabolic characteristics of the sample according to clinical condition.
Nonfrailty (n = 127)
Frailty (n = 34)
Age (years)
84.3 ± 4.1
84.5 ± 4.0
0.800
Body mass (Kg)
64.0 ± 12.7
62.9 ± 11.6
0.663
Height (m)
1.6 ± 0.1
1.5 ± 0.1
0.314
BMI (kg.m−2)
26.1 ± 4.6
26.3 ± 4.0
0.748
Body fat (%)
32.6 ± 9.9
32.7 ± 9.1
0.975
WC (cm)
92.9 ± 12.2
95.4 ± 12.7
0.338
HC (cm)
99.9 ± 9.7
99.8 ± 9.2
0.967
W-H ratio
0.9 ± 0.1
1.0 ± 0.1
0.128
MMSE (score)
20.7 ± 6.5
18.5 ± 6.3
0.087
Glucose (mg/dL)
93.0 (87.0–105.0)
94.0 (78.5–105.5)
0.541
TC (mg.dl−1)
184.0 (163.0–208.0)
180.0 (159.2–186.5)
0.117
HDL-c (mg.dl−1)
50.0 (41.0–56.0)
50.0 (42.8–57.0)
0.639
LDL-c (mg.dl−1)
109.0 (87.0–131.0)
104.5 (83.0–115.5)
0.084
TG (mg.dl−1)
125.0 (97.0–152.0)
129.0 (91.8–148.2)
0.988
C-RP (mg.dl−1)
0.4 (0.4–0.4)
0.4 (0.4–0.7)
0.511
HbA1c (mg.dl−1)
5.7 (5.5–6.1)
5.8 (5.5–6.2)
0.954
IFNγ (pg/ml)
5.9 (5.4–6.6)
5.5 (4.9–6.5)
0.283
TNFα (pg/ml)
1.7 (1.1–2.4)
1.7 (1.0–2.6)
0.987
IL-10 (pg/ml)
3.4 (2.9–4.0)
3.3 (2.8–3.8)
0.615
IL-6 (pg/ml)
4.7 (3.5–8.8)
6.4 (3.8–12.8)
0.350
IL-4 (pg/ml)
1.7 (1.3–2.1)
1.6 (1.0–1.9)
0.192
IL-2 (pg/ml)
9.0 (8.6–9.9)
9.3 (8.6–9.8)
0.546
Grip strength (kgf)
18.6 (14.0–24.6)
16.1 (13.6–18.7)
0.041
Walking time (s)
5.0 (4.3–6.7)
7.0 (5.6–8.8)
0.001
Current diabetes (%)†
27.0
40.0
0.173
Current SAH (%)†
80.2
87.5
0.347
Current osteoporosis (%)†
44.0
39.3
0.527
Current arthritis (%)†
32.2
30.8
0.622
Current depression (%)†
29.5
25.9
0.685
History of cancer (%)†
16.7
21.4
0.546
BMI = body mass index, C-RP = C-reactive protein, HC = hip circumference, MMSE = Mini Mental State Examination, TC = total cholesterol, TG = triglycerides, HbA1c = glycated hemoglobin A1c, SAH = systemic arterial hypertension, WC = waist circumference, and W-H = waist-to-hip. t-test for independent samples, data as mean and standard deviation.Nonparametric test of Mann–Whitney, data as median and interquartile range. †Chi-square test, data as within-group proportions.
