Table of Contents
Journal of Biomarkers
Volume 2013, Article ID 960125, 12 pages
http://dx.doi.org/10.1155/2013/960125
Research Article

Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats

1Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Chennai 600113, India
2Department of Biochemistry, Asan Memorial Dental College & Hospital, Asan Nagar, Chengalpattu 603105, India

Received 14 June 2012; Accepted 11 August 2012

Academic Editor: A. S. Jaffe

Copyright © 2013 Kandaswamy Selvakumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. W. Robertson and G. Ludewig, “Polychlorinated Biphenyl (PCB) carcinogenicity with special emphasis on airborne PCBs,” Gefahrstoffe Reinhaltung der Luft, vol. 71, no. 1-2, pp. 25–32, 2011. View at Google Scholar · View at Scopus
  2. L. A. Rodenburg, J. Guo, S. Du, and G. J. Cavallo, “Evidence for unique and ubiquitous environmental sources of 3,3-dichlorobiphenyl (PCB 11),” Environmental Science and Technology, vol. 44, no. 8, pp. 2816–2821, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Norström, G. Czub, M. S. McLachlan, D. Hu, P. S. Thorne, and K. C. Hornbuckle, “External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment,” Environment International, vol. 36, no. 8, pp. 855–861, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. R. G. Allen and M. Tresini, “Oxidative stress and gene regulation,” Free Radical Biology and Medicine, vol. 28, no. 3, pp. 463–499, 2000. View at Publisher · View at Google Scholar · View at Scopus
  5. A. Pilorget, V. Berthet, J. Luis, A. Moghrabi, B. Annabi, and R. Béliveau, “Medulloblastoma cell invasion is inhibited by green tea (-)epigallocatechin-3-gallate,” Journal of Cellular Biochemistry, vol. 90, no. 4, pp. 745–755, 2003. View at Publisher · View at Google Scholar · View at Scopus
  6. Y. Morimoto, T. Yasuhara, A. Sugimoto et al., “Anti-allergic substances contained in the pollen of Cryptomeria japonica possess diverse effects on the degranulation of RBL-2H3 cells,” Journal of Pharmacological Sciences, vol. 92, no. 3, pp. 291–295, 2003. View at Google Scholar · View at Scopus
  7. A. Novakovic, L. Gojkovic-Bukarica, M. Peric et al., “The mechanism of endothelium-independent relaxation induced by the wine polyphenol resveratrol in human internal mammary artery,” Journal of Pharmacological Sciences, vol. 101, no. 1, pp. 85–90, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. S. R. Lee, S. I. Suh, and S. P. Kim, “Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils,” Neuroscience Letters, vol. 287, no. 3, pp. 191–194, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. H. P. Kim, K. H. Son, H. W. Chang, and S. S. Kang, “Anti-inflammatory plant flavonoids and cellular action mechanisms,” Journal of Pharmacological Sciences, vol. 96, no. 3, pp. 229–245, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. A. I. Potapovich and V. A. Kostyuk, “Comparative study of antioxidant properties and cytoprotective activity of flavonoids,” Biochemistry, vol. 68, no. 5, pp. 514–519, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Yokozawa, D. Y. Rhyu, and E. J. Cho, “(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors,” Journal of Pharmacy and Pharmacology, vol. 56, no. 2, pp. 231–239, 2004. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Guardia, A. E. Rotelli, A. O. Juarez, and L. E. Pelzer, “Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat,” Farmaco, vol. 56, no. 9, pp. 683–687, 2001. View at Publisher · View at Google Scholar · View at Scopus
  13. J. P. H. Fee, G. W. Black, and J. W. Dundee, “A prospective study of liver enzyme and other changes following repeat administration of halothane and enflurane,” British Journal of Anaesthesia, vol. 51, no. 12, pp. 1133–1141, 1979. View at Google Scholar · View at Scopus
  14. D. K. Spracklin, K. E. Thummel, and E. D. Kharasch, “Human reductive halothane metabolism in vitro is catalyzed by cytochrome P450 2A6 and 3A4,” Drug Metabolism and Disposition, vol. 24, no. 9, pp. 976–983, 1996. View at Google Scholar · View at Scopus
  15. M. Naziroǧlu, “Protective role of intraperitoneally administered vitamin E and selenium in rats anesthetized with enflurane,” Biological Trace Element Research, vol. 69, no. 3, pp. 199–209, 1999. View at Google Scholar · View at Scopus
  16. A. Z. Karakilcik, M. Zerin, O. Arslan, Y. Nazligul, and H. Vural, “Effects of vitamin C and E on liver enzymes and biochemical parameters of rabbits exposed to aflatoxin B1,” Veterinary and Human Toxicology, vol. 46, no. 4, pp. 190–192, 2004. View at Google Scholar · View at Scopus
  17. S. P. Netke, M. W. Roomi, C. Tsao, and A. Niedzwiecki, “Ascorbic acid protects guinea pigs from acute aflatoxin toxicity,” Toxicology and Applied Pharmacology, vol. 143, no. 2, pp. 429–435, 1997. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Selvakumar, S. Bavithra, M. Suganthi et al., “Protective role of quercetin on PCBs-induced oxidative stress and apoptosis in hippocampus of adult rats,” Neurochemical Research, vol. 37, no. 4, pp. 708–721, 2012. View at Google Scholar
  19. S. Bavithra, K. Selvakumar, R. Pratheepa Kumari, G. Krishnamoorthy, P. Venkataraman, and J. Arunakaran, “Polychlorinated biphenyl (PCBs)-induced oxidative stress plays a critical role on cerebellar dopaminergic receptor expression: ameliorative role of quercetin,” Neurotoxicity Research, vol. 21, no. 2, pp. 149–159, 2012. View at Publisher · View at Google Scholar · View at Scopus
  20. R. Pratheepa Kumari, K. Selvakumar, S. Bavithra, R. Zumaana, G. Krishnamoorthy, and J. Arunakaran, “Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male rats,” Neurochemical Research, vol. 36, no. 8, pp. 1344–1352, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. P. Venkataraman, R. Muthuvel, G. Krishnamoorthy et al., “PCB (Aroclor 1254) enhances oxidative damage in rat brain regions: protective role of ascorbic acid,” NeuroToxicology, vol. 28, no. 3, pp. 490–498, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. A. Gurel, O. Coskun, F. Armutcu, M. Kanter, and O. A. Ozen, “Vitamin E against oxidative damage caused by formaldehyde in frontal cortex and hippocampus: biochemical and histological studies,” Journal of Chemical Neuroanatomy, vol. 29, no. 3, pp. 173–178, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. W. J. Crinnion, “Polychlorinated biphenyls: persistent pollutants with immunological, neurological, and endocrinological consequences,” Alternative Medicine Review, vol. 16, no. 1, pp. 5–13, 2011. View at Google Scholar · View at Scopus
  24. L. J. Teppema, D. Nieuwenhuijs, E. Sarton et al., “Antioxidants prevent depression of the acute hypoxic ventilatory response by subanaesthetic halothane in men,” Journal of Physiology, vol. 544, no. 3, pp. 931–938, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Durak, O. F. Bilgen, T. Kaleli, P. Tuncel, R. Özbek, and K. Turan, “Antioxidant effect of α-tocopherol on fracture haematoma in rabbits,” Journal of International Medical Research, vol. 24, no. 5, pp. 419–424, 1996. View at Google Scholar · View at Scopus
  26. R. C. Lind, A. J. Gandolfi, and M. P. De La Hall, “Age and gender influence halothane-associated hepatotoxicity in strain 13 guinea pigs,” Anesthesiology, vol. 71, no. 6, pp. 878–884, 1989. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Gil, V. Fiserova-Bergerova, and N. H. Altman, “Hepatic protection from chemical injury by isoflurane,” Anesthesia and Analgesia, vol. 67, no. 9, pp. 860–867, 1988. View at Google Scholar · View at Scopus
  28. D. C. Ray and G. B. Drummond, “Halothane hepatitis,” British Journal of Anaesthesia, vol. 67, no. 1, pp. 84–99, 1991. View at Google Scholar · View at Scopus
  29. M. G. Binker, A. A. Binker-Cosen, D. Richards, H. Y. Gaisano, R. H. de Cosen, and L. I. Cosen-Binker, “Chronic stress sensitizes rats to pancreatitis induced by cerulein: role of TNF-α,” World Journal of Gastroenterology, vol. 16, no. 44, pp. 5565–5581, 2010. View at Publisher · View at Google Scholar · View at Scopus
  30. T. Balani, S. Agrawal, and A. M. Thaker, “Hematological and biochemical changes due to short-term oral administration of imidacloprid,” Toxicology International, vol. 18, no. 1, pp. 2–4, 2011. View at Publisher · View at Google Scholar · View at Scopus
  31. M. G. Shalan, M. S. Mostafa, M. M. Hassouna, S. E. H. El-Nabi, and A. El-Refaie, “Amelioration of lead toxicity on rat liver with Vitamin C and silymarin supplements,” Toxicology, vol. 206, no. 1, pp. 1–15, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Murugesan, T. Muthusamy, K. Balasubramanian, and J. Arunakaran, “Polychlorinated biphenyl (Aroclor 1254) inhibits testosterone biosynthesis and antioxidant enzymes in cultured rat Leydig cells,” Reproductive Toxicology, vol. 25, no. 4, pp. 447–454, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Krishnamoorthy, P. Murugesan, R. Muthuvel et al., “Effect of Aroclor 1254 on Sertoli cellular antioxidant system, androgen binding protein and lactate in adult rat in vitro,” Toxicology, vol. 212, no. 2-3, pp. 195–205, 2005. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Selvakumar, L. Sheerin Banu, G. Krishnamoorthy, P. Venkataraman, P. Elumalai, and J. Arunakaran, “Differential expression of androgen and estrogen receptors in PCB (Aroclor 1254)-exposed rat ventral prostate: impact of alpha-tocopherol,” Experimental and Toxicologic Pathology, vol. 63, no. 1-2, pp. 105–112, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Venkataraman, G. Krishnamoorthy, K. Selvakumar, and J. Arunakaran, “Oxidative stress alters creatine kinase system in serum and brain regions of polychlorinated biphenyl (Aroclor 1254)-exposed rats: protective role of melatonin,” Basic and Clinical Pharmacology and Toxicology, vol. 105, no. 2, pp. 92–97, 2009. View at Publisher · View at Google Scholar · View at Scopus
  36. P. M. Amália, M. N. Possa, M. C. Augusto, and L. S. Francisca, “Quercetin prevents oxidative stress in cirrhotic rats,” Digestive Diseases and Sciences, vol. 52, no. 10, pp. 2616–2621, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. E. J. Choi, K. M. Chee, and B. H. Lee, “Anti- and prooxidant effects of chronic quercetin administration in rats,” European Journal of Pharmacology, vol. 482, no. 1–3, pp. 281–285, 2003. View at Publisher · View at Google Scholar · View at Scopus
  38. H. B. Rubins, S. J. Robins, D. Collins et al., “Gemfibrozil for the secondary prevention of coronary heart disease in men with low levels of high-density lipoprotein cholesterol,” New England Journal of Medicine, vol. 341, no. 6, pp. 410–418, 1999. View at Publisher · View at Google Scholar · View at Scopus
  39. R. P. Robertson, J. Harmon, P. O. T. Tran, and V. Poitout, “Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes,” Diabetes, vol. 53, no. 1, supplement, pp. S119–S124, 2004. View at Google Scholar · View at Scopus
  40. G. M. Williams and M. J. Iatropoulos, “Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity,” Toxicologic Pathology, vol. 30, no. 1, pp. 41–53, 2002. View at Publisher · View at Google Scholar · View at Scopus
  41. Y. Shenker, R. S. Sider, E. A. Ostafin, and R. J. Grekin, “Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema,” Journal of Clinical Investigation, vol. 76, no. 4, pp. 1684–1687, 1985. View at Google Scholar · View at Scopus
  42. S. K. Panchal, L. Ward, and L. Brown, “Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats,” European Journal of Nutrition. In press.
  43. C. Betterle, C. Dal Pra, F. Mantero, and R. Zanchetta, “Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction,” Endocrine Reviews, vol. 23, no. 3, pp. 327–364, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Kapitulnik, R. Horner Mibashan, and S. H. Blondheim, “Increase in bilirubin binding affinity of serum with age of infant,” Journal of Pediatrics, vol. 86, no. 3, pp. 442–445, 1975. View at Google Scholar · View at Scopus
  45. K. Senthilkumar, R. Arunkumar, P. Elumalai et al., “Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3),” Cell Biochemistry and Function, vol. 29, no. 2, pp. 87–95, 2011. View at Publisher · View at Google Scholar · View at Scopus
  46. K. Senthilkumar, P. Elumalai, R. Arunkumar et al., “Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3),” Molecular and Cellular Biochemistry, vol. 344, no. 1-2, pp. 173–184, 2010. View at Publisher · View at Google Scholar · View at Scopus
  47. F. Pu, K. Mishima, K. Irie et al., “Neuroprotective effects of quercetin and rutin on spatial memory impairment in an 8-arm radial maze task and neuronal death induced by repeated cerebral ischemia in rats,” Journal of Pharmacological Sciences, vol. 104, no. 4, pp. 329–334, 2007. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Anbalagan, P. Kanagaraj, N. Srinivasan, M. M. Aruldhas, and J. Arunakaran, “Effect of polychlorinated biphenyl, Aroclor 1254 on rat epididymis,” Indian Journal of Medical Research, vol. 118, pp. 236–242, 2003. View at Google Scholar · View at Scopus
  49. P. Venkataraman, K. Selvakumar, G. Krishnamoorthy et al., “Effect of melatonin on PCB (Aroclor 1254) induced neuronal damage and changes in Cu/Zn superoxide dismutase and glutathione peroxidase-4 mRNA expression in cerebral cortex, cerebellum and hippocampus of adult rats,” Neuroscience Research, vol. 66, no. 2, pp. 189–197, 2010. View at Publisher · View at Google Scholar · View at Scopus