Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase?

Table 4

Performance of significantly downregulated candidate genes to discriminate between malignant and nonmalignant samples*.

Gene	Sensitivity (95% CI)	Specificity (95% CI)	AUC	𝑃 value	Standard error
GSTP1	90% (78.2–96.7)	78% (64.0–88.5)	0.884	<0.0001	0.0369
GADD45A	90% (78.2–96.7)	58% (43.2–71.8)	0.841	<0.0001	0.0407
SARS	90% (78.2–96.7)	48% (33.7–62.6)	0.816	<0.0001	0.044
SPRY4	90% (78.2–96.7)	16% (7.2–29.1)	0.644	0.0085	0.0549

∗Five candidate genes that show significant downregulation on Wilcoxon signed rank test and further performance assessed by ROC curve analysis. 90% sensitivity and specificity with 95% confidence interval (95% CI).