Journal of Biomarkers / 2014 / Article / Tab 4

Research Article

Functional Epigenetic Analysis of Prostate Carcinoma: A Role for Seryl-tRNA Synthetase?

Table 4

Performance of significantly downregulated candidate genes to discriminate between malignant and nonmalignant samples*.

GeneSensitivity (95% CI)Specificity (95% CI)AUC valueStandard error

GSTP190% (78.2–96.7)78% (64.0–88.5)0.884 0.00010.0369
GADD45A90% (78.2–96.7)58% (43.2–71.8)0.841 0.00010.0407
SARS90% (78.2–96.7)48% (33.7–62.6)0.816 0.00010.044
SPRY490% (78.2–96.7)16% (7.2–29.1)0.6440.00850.0549

Five candidate genes that show significant downregulation on Wilcoxon signed rank test and further performance assessed by ROC curve analysis. 90% sensitivity and specificity with 95% confidence interval (95% CI).

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