Table of Contents
Journal of Biomarkers
Volume 2014 (2014), Article ID 596503, 4 pages
http://dx.doi.org/10.1155/2014/596503
Research Article

Biomarkers Predict Relapse in Granulomatosis with Polyangiitis

1Department of Immunology, Trinity College Dublin, St. James’s Hospital, Dublin 8, Ireland
2Institute of Molecular Medicine, Trinity College Dublin, St. James’s Hospital, Dublin 8, Ireland

Received 31 October 2013; Revised 21 March 2014; Accepted 5 April 2014; Published 30 April 2014

Academic Editor: Philip Thomas

Copyright © 2014 Patrick C. P. Hogan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. J. van der Woude, N. Rasmussen, S. Lobatto et al., “Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener’s granulomatosis,” The Lancet, vol. 1, no. 8426, pp. 425–429, 1985. View at Google Scholar
  2. J. C. Jennette, J. R. Hoidal, and R. J. Falk, “Specificity of anti-neutrophil cytoplasmic autoantibodies for proteinase 3,” Blood, vol. 75, no. 11, pp. 2263–2264, 1990. View at Google Scholar · View at Scopus
  3. W. Koldingsnes and H. Nossent, “Predictors of survival and organ damage in Wegener's granulomatosis,” Rheumatology, vol. 41, no. 5, pp. 572–581, 2002. View at Google Scholar · View at Scopus
  4. C. P.-D. Despujol, J. Pouchot, C. Pagnoux, J. Coste, and L. Guillevin, “Predictors at diagnosis of a first Wegener's granulomatosis relapse after obtaining complete remission,” Rheumatology, vol. 49, no. 11, Article ID keq244, pp. 2181–2190, 2010. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Pagnoux, S. L. Hogan, H. Chin et al., “Predictors of treatment resistance and relapse in antineutrophil cytoplasmic antibody—associated small-vessel vasculitis,” Arthritis and Rheumatism, vol. 58, no. 9, pp. 2908–2918, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. C. A. Stegeman, J. W. C. Tervaert, P. E. De Jong, and C. G. M. Kallenberg, “Trimethoprim-sulfamethoxazole (Co-trimoxazole) for the prevention of relapses of Wegener's granulomatosis,” New England Journal of Medicine, vol. 335, no. 1, pp. 16–20, 1996. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Mukhtyar, O. Flossmann, B. Hellmich et al., “Outcomes from studies of antineutrophil cytoplasm antibody associated vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force,” Annals of the Rheumatic Diseases, vol. 67, no. 7, pp. 1004–1010, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Rasmussen, A. Salmela, A. Ekstrand et al., “Changes in proteinase 3 anti-neutrophil cytoplasm autoantibody levels in early systemic granulomatosis with polyangiitis (Wegener's) may reflect treatment rather than disease activity,” Clinical and Experimental Rheumatology, vol. 31, no. 1, supplement 75, pp. S38–S44, 2013. View at Google Scholar
  9. G. Tomasson, P. C. Grayson, A. D. Mahr, M. LaValley, and P. A. Merkel, “Value of ANCA measurements during remission to predict a relapse of ANCA-associated vasculitis—a meta-analysis,” Rheumatology, vol. 51, no. 1, pp. 100–109, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. C. A. Staegeman, “Anti-neutrophil cytoplasmic antibody (ANCA) levels directed against proteinase-3 and myeloperoxidase are helpful in predicting disease relapse in ANCA-associated small-vessel vasculitis,” Nephrology Dialysis Transplantation, vol. 17, no. 12, pp. 2077–2080, 2002. View at Google Scholar · View at Scopus
  11. X. Bosch, A. Guilabert, and J. Font, “Antineutrophil cytoplasmic antibodies,” The Lancet, vol. 368, no. 9533, pp. 404–418, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. A. I. Kälsch, E. Csernok, D. Münch et al., “Use of highly sensitive C-reactive protein for followup of Wegener's granulomatosis,” Journal of Rheumatology, vol. 37, no. 11, pp. 2319–2325, 2010. View at Google Scholar
  13. L. A. Hirano, S. T. Bogardus Jr., S. Saluja, L. Leo-Summers, and S. K. Inouye, “Clinical yield of computed tomography brain scans in older general medical patients,” Journal of the American Geriatrics Society, vol. 54, no. 4, pp. 587–592, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Mukhtyar, L. Guillevin, M. C. Cid et al., “EULAR recommendations for the management of primary small and medium vessel vasculitis,” Annals of the Rheumatic Diseases, vol. 68, no. 3, pp. 310–317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. C. A. Langford, “Update on the treatment of granulomatosis with polyangiitis (Wegener's),” Current Treatment Options in Cardiovascular Medicine, vol. 14, no. 2, pp. 164–176, 2012. View at Google Scholar
  16. G. S. Hoffman, G. S. Kerr, R. Y. Leavitt et al., “Wegener granulomatosis: an analysis of 158 patients,” Annals of Internal Medicine, vol. 116, no. 6, pp. 488–498, 1992. View at Google Scholar · View at Scopus