579402.fig.004
Figure 4: Catalytic cycle of Enzyme I in reduced form. Designations 𝑌 : the sum of the concentrations of Nonphosphorylated monomer forms; 𝑌 𝑃 : the sum of the concentrations of the phosphorylated monomer forms; 𝑍 : the sum of the concentrations of Nonphosphorylated dimer forms; 𝑍 P: the sum of the concentrations of singly-phosphorylated dimer forms; 𝑍 P2: the sum of the concentrations of the doubly-phosphorylated dimer forms. New rates correspond to the sums of the elementary processes rates (see explanation in the main text and Supplement). Dashed lines: phosphotransfer to HPr, dotted lines: dissociation (dimerization) reactions, other reactions are shown by the solid lines.