Table of Contents
Journal of Biophysics
Volume 2012, Article ID 830741, 7 pages
http://dx.doi.org/10.1155/2012/830741
Research Article

Cytoskeletal Strains in Modeled Optohydrodynamically Stressed Healthy and Diseased Biological Cells

1Regenerative Bioengineering Laboratory, Department of Biology, Science Research & Teaching Center (SRTC), Portland State University, P.O. Box 751, Portland, OR 97207, USA
2Department of Surgery, Oregon Health & Science University, Portland, OR 97239, USA
3Center for Allaying Health Disparities through Research and Education (CADRE) and Department of Mathematics & Computer Science, Central State University, Wilberforce, OH 45384, USA

Received 27 September 2012; Revised 6 November 2012; Accepted 6 November 2012

Academic Editor: George Perry

Copyright © 2012 Sean S. Kohles et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. Y. H. Lee and C. T. Lim, “Biomechanics approaches to studying human diseases,” Trends in Biotechnology, vol. 25, no. 3, pp. 111–118, 2007. View at Publisher · View at Google Scholar · View at Scopus
  2. Z. D. Wilson and S. S. Kohles, “Two-dimensional modeling of nanomechanical stresses-strains in healthy and diseased single-cells during microfluidic manipulation,” Journal of Nanotechnology in Engineering and Medicine, vol. 1, no. 2, 2010. View at Google Scholar
  3. S. Grad, D. Eglin, M. Alini, and M. J. Stoddart, “Physical stimulation of chondrogenic cells in vitro: a review,” Clinical Orthopaedics and Related Research, vol. 469, no. 10, pp. 2764–2772, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. M. G. Ehrlich, A. L. Armstrong, B. V. Treadwell, and H. J. Mankin, “The role of proteases in the pathogenesis of osteoarthritis,” Journal of Rheumatology, vol. 14, pp. 30–32, 1987. View at Google Scholar · View at Scopus
  5. S. S. Kohles, C. G. Wilson, and L. J. Bonassar, “A mechanical composite spheres analysis of engineered cartilage dynamics,” Journal of Biomechanical Engineering, vol. 129, no. 4, pp. 473–480, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. R. D. González-Cruz, V. C. Fonseca, and E. M. Darling, “Cellular mechanical properties reflect the differentiation potential of adipose-derived mesenchymal stem cells,” Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 24, pp. E1523–E1529, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. S. E. Cross, Y. S. Jin, J. Rao, and J. K. Gimzewski, “Nanomechanical analysis of cells from cancer patients,” Nature Nanotechnology, vol. 2, no. 12, pp. 780–783, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. N. Nève, J. K. Lingwood, J. Zimmerman, S. S. Kohles, and D. C. Tretheway, “The μPIVOT: an integrated particle image velocimeter and optical tweezers instrument for microenvironment investigations,” Measurement Science and Technology, vol. 19, no. 9, Article ID 095403, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. L. M. Walker, Å. Holm, L. Cooling et al., “Mechanical manipulation of bone and cartilage cells with optical tweezers,” FEBS Letters, vol. 459, no. 1, pp. 39–42, 1999. View at Google Scholar
  10. J. Guck, R. Ananthakrishnan, H. Mahmood, T. J. Moon, C. C. Cunningham, and J. Käs, “The optical stretcher: a novel laser tool to micromanipulate cells,” Biophysical Journal, vol. 81, no. 2, pp. 767–784, 2001. View at Google Scholar · View at Scopus
  11. G. Bao and S. Suresh, “Cell and molecular mechanics of biological materials,” Nature Materials, vol. 2, no. 11, pp. 715–725, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. S. S. Kohles, N. Nève, J. D. Zimmerman, and D. C. Tretheway, “Mechanical stress analysis of microfluidic environments designed for isolated biological cell investigations,” Journal of Biomechanical Engineering, vol. 131, no. 12, Article ID 121006, 10 pages, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. A. K. Saha, Y. Liang, and S. S. Kohles, “Biokinetic mechanisms linked with musculoskeletal health disparities: stochastic models applying Tikhonov's theorem to biomolecule Homeostasis,” Journal of Nanotechnology in Engineering and Medicine, vol. 2, no. 2, Article ID 021004, 9 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. S. S. Kohles, “Opto-hydrodynamic trapping for multiaxial single-cell biomechanics,” in Advances in Cell Mechanics, Advances in Materials and Mechanics (AMM), S. Li and B. Sun, Eds., pp. 237–255, Springer, New York, NY, USA, 2011. View at Google Scholar
  15. S. S. Kohles, Y. Liang, and A. K. Saha, “Volumetric stress-strain analysis of optohydrodynamically suspended biological cells,” Journal of Biomechanical Engineering, vol. 133, no. 1, Article ID 011004, 6 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Neve, S. S. Kohles, S. R. Winn, and D. C. Tretheway, “Manipulation of suspended single cells by microfluidics and optical tweezers,” Cellular and Molecular Bioengineering, vol. 3, no. 3, pp. 213–228, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. L. G. Leal, Advanced Transport Phenomena: Fluid Mechanics and Convective Transport Processes, Cambridge University Press, New York, NY, USA, 2007.
  18. T. C. Papanastasiou, G. C. Georgio, and A. N. Alexandrou, Viscous Fluid Flow, CRC Press, New York, NY, USA, 2000.
  19. R. D. Cook and W. C. Young, Advanced Mechanics of Materials, Macmillan, New York, NY, USA, 1985.
  20. H. L. Langhaar, Energy Methods in Applied Mechanics, John Wiley & Sons, New York, NY, USA, 1962.
  21. F. P. Beer, E. R. Johnston Jr., and J. T. DeWolf, Mechanics of Materials, McGraw-Hill, Boston, Mass, USA, 3rd edition, 2002.
  22. X. Zeng, S. Li, and S. S. Kohles, “Multiscale biomechanical modeling of stem cell-extracellular matrix interactions,” in Advances in Cell Mechanics, Advances in Materials and Mechanics (AMM), S. Li and B. Sun, Eds., pp. 27–54, Springer, New York, NY, USA, 2011. View at Google Scholar
  23. C. T. Lim, E. H. Zhou, and S. T. Quek, “Mechanical models for living cells—a review,” Journal of Biomechanics, vol. 39, no. 2, pp. 195–216, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. G. Holzapfel, Nonlinear Solid Mechanics, Wiley, Chichester, UK, 2000.
  25. J. C. M. Lee and D. E. Discher, “Deformation-enhanced fluctuations in the red cell skeleton with theoretical relations to elasticity, connectivity, and spectrin unfolding,” Biophysical Journal, vol. 81, no. 6, pp. 3178–3192, 2001. View at Google Scholar · View at Scopus
  26. F. Guilak and V. C. Mow, “The mechanical environment of the chondrocyte: a biphasic finite element model of cell-matrix interactions in articular cartilage,” Journal of Biomechanics, vol. 33, no. 12, pp. 1663–1673, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. W. Kim, D. C. Tretheway, and S. S. Kohles, “An inverse method for predicting tissue-level mechanics from cellular mechanical input,” Journal of Biomechanics, vol. 42, no. 3, pp. 395–399, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. P. A. Janmey and C. A. McCulloch, “Cell mechanics: integrating cell responses to mechanical stimuli,” Annual Review of Biomedical Engineering, vol. 9, pp. 1–34, 2007. View at Publisher · View at Google Scholar · View at Scopus