Cell Matrix Remodeling Ability Shown by Image Spatial Correlation
Figure 4
Comparison of collagen remodeling degree with different cell lines. The degree of collagen remodeling by MCF-7, NIH/3T3, and MDA-MB-231 cell lines over 4 days of incubation was evaluated by of the low spatial frequency component (the blue curve in Figure 1). Of all three cell lines, MDA-MB-231 showed the highest degree of collagen remodeling, and the collagen compaction degree increases over 4-day period. MCF-7 exhibits the lowest degree of collagen compaction and has the value similar to the collagen matrix without cells. Dashed line shows the average value of collagen matrix without cells at day 1. * indicates that the standard deviation is significantly different from the baseline control (collagen matrix without cells for each equivalent age of the sample, by -test).
