Table of Contents
Journal of Biophysics
Volume 2015, Article ID 529746, 6 pages
Research Article

On the Role of the Blood Vessel Endothelial Microvilli in the Blood Flow in Small Capillaries

1Department of Physics, University of Puerto Rico (UPR), San Juan, PR 00931, USA
2Department of Neuroscience, Central University of Caribbean (UCC), Bayamon, PR 00960, USA
3Department of Physiology, Central University of Caribbean (UCC), Bayamon, PR 00960, USA
4Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences (UAMS), Little Rock, AR 72205, USA
5Department of Vertebrates Zoology, Lomonosov Moscow State University (MSU), Moscow 119234, Russia
6Faculty of Sciences and Technology, University of Algarve (UAlg), 8005-139 Faro, Portugal

Received 3 August 2015; Accepted 13 October 2015

Academic Editor: Rizwan Hasan Khan

Copyright © 2015 Vladimir Makarov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Endothelial microvilli that protrude into the capillary lumen, although invisible in the optical microscopy, may play an important role in the blood flow control in the capillaries. Because of the plug effects, the width of the gap between the capillary wall and the blood cell is especially critical for the blood flow dynamics in capillaries, while microvilli located on the capillary wall can easily control the velocity of the blood flow. We report that microvilli in the capillaries of different vertebrate species have similar characteristics and density, suggesting similarities between the respective regulation mechanisms. A simplified physical model of the capillary effective diameter control by the microvilli is presented.