Table of Contents
Journal of Biophysics
Volume 2015 (2015), Article ID 686249, 14 pages
http://dx.doi.org/10.1155/2015/686249
Research Article

Informational Theory of Aging: The Life Extension Method Based on the Bone Marrow Transplantation

1Institute of Cell Biophysics, Russian Academy of Sciences, Institutskaya Street 3, Pushchino, Moscow 142290, Russia
2Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Baltiyskaya Street 8, Moscow 125315, Russia

Received 30 May 2015; Revised 10 August 2015; Accepted 12 August 2015

Academic Editor: Jianwei Shuai

Copyright © 2015 Alexey V. Karnaukhov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The method of lifespan extension that is a practical application of the informational theory of aging is proposed. In this theory, the degradation (error accumulation) of the genetic information in cells is considered a main cause of aging. According to it, our method is based on the transplantation of genetically identical (or similar) stem cells with the lower number of genomic errors to the old recipients. For humans and large mammals, this method can be realized by cryopreservation of their own stem cells, taken in a young age, for the later autologous transplantation in old age. To test this method experimentally, we chose laboratory animals of relatively short lifespan (mouse). Because it is difficult to isolate the required amount of the stem cells (e.g., bone marrow) without significant damage for animals, we used the bone marrow transplantation from sacrificed inbred young donors. It is shown that the lifespan extension of recipients depends on level of their genetic similarity (syngeneity) with donors. We have achieved the lifespan increase of the experimental mice by 34% when the transplantation of the bone marrow with high level of genetic similarity was used.