Trends in the Binding of Cell Penetrating Peptides to siRNA: A Molecular Docking Study

Figure 6

Predicted structures of CPP-GAPDH ((a) A-form; (b) B-form) complex from docking calculations. Pictures show the HIV-1 gp41 (1–23) peptide representing the hydrophobic class of CPPs. The peptide to siRNA ratios are 1 : 1 (left), 5 : 1 (center), and 30 : 1 (right), respectively.

(a)

(b)