Table of Contents
Journal of Blood Transfusion
Volume 2012, Article ID 102809, 9 pages
http://dx.doi.org/10.1155/2012/102809
Research Article

Quality of Red Blood Cells Isolated from Umbilical Cord Blood Stored at Room Temperature

1Department of Laboratory Medicine and Pathology, University of Alberta, 8249-114 Street, Edmonton, AB, Canada T6G 2R8
2Alberta Cord Blood Bank, Suite 408 College Plaza, 8215-112 Street, Edmonton, AB, Canada T6G 2C8
3Research and Development, Canadian Blood Services, 8249-114 Street, Edmonton, AB, Canada T6G 2R8

Received 16 October 2011; Accepted 9 December 2011

Academic Editor: Niranjan Bhattacharya

Copyright © 2012 Mariia Zhurova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Red blood cells (RBCs) from cord blood contain fetal hemoglobin that is predominant in newborns and, therefore, may be more appropriate for neonatal transfusions than currently transfused adult RBCs. Post-collection, cord blood can be stored at room temperature for several days before it is processed for stem cells isolation, with little known about how these conditions affect currently discarded RBCs. The present study examined the effect of the duration cord blood spent at room temperature and other cord blood characteristics on cord RBC quality. RBCs were tested immediately after their isolation from cord blood using a broad panel of quality assays. No significant decrease in cord RBC quality was observed during the first 65 hours of storage at room temperature. The ratio of cord blood to anticoagulant was associated with RBC quality and needs to be optimized in future. This knowledge will assist in future development of cord RBC transfusion product.