CRASH-2 Study of Tranexamic Acid to Treat Bleeding in Trauma Patients: A Controversy Fueled by Science and Social Media
Table 2
Review articles on TXA use in trauma.
Title
Author(s)
Description
Year
Critique
Tranexamic Acid for Trauma Patients: A Critical Review of the Literature [14]
Cap et al.
Systematic review of TXA
2011
Favorable towards CRASH-2 findings and recommends use in combat situations and bleeding trauma patients
Tranexamic Acid and Trauma: Current Status and Knowledge Gaps with Recommended Research Priorities [15]
Pusateri et al., Department of Defense
Systematic review of TXA
2013
Identifies “knowledge gaps” in the CRASH-2 trial: () lack of clarity of reporting of monitoring, complications, () no transfusion benefit, and () data not robust
Tranexamic Acid in Trauma: How Should We Use It? [16]
Napolitano et al.
Systematic review of TXA
2013
Major knowledge gaps: () recruitment, () 100% follow-up, () 50% received transfusion, () survival benefit not a function of transfusion, () TBI greatest cause of death, () low rate of thrombosis, and () other shortcomings noted
