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| Title | Author(s) | Description | Year | Outcomes | Recommendations |
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| Military Application of Tranexamic Acid in Trauma Emergency Resuscitation (MATTERs) study [17] | Morrison et al. | Retrospective observational study; 896 pts with combat injury and at least one unit of PRBCs | 2011 | TXA significant survivor benefit with reduced blood utilization and increased rate of VTE | TXA should be incorporated into trauma resuscitation protocols for “severe wartime injury and hemorrhage” |
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| Tranexamic Acid Use in Trauma: Effective but Not without Consequences [18] | Swendsen et al. | Retrospective multi cohort study; 126 trauma pts, 93 straight to OR/IR of whom 46 received TXA | 2013 | TXA mortality benefit, increased VTE, trend towards increased AKI, and no transfusions differences | “In civilian trauma, early TXA administration confers early survival advantage without affecting blood product usage but may increase the risk of DVT/PE and AKI” |
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| Do All Trauma Patients Benefit from Tranexamic Acid? [19] | Valle et al. | Retrospective, observational single-center study; 1,217 trauma patients requiring OR/transfusions | 2014 | TXA group that had increased mortality, PRBCs, and crystalloid | “Prospective studies are needed to further identify conditions that may override the benefits from TXA” |
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| Tranexamic Acid Use in Severely Injured Civilian Patients and the Effects on Outcomes [20] |
Cole et al. | Prospective cohort study; 385 severely injured (ISS > 15), civilian pts. Focused on 131 shocked pts | 2015 | TXA mortality benefit for shocked patients not statistically significant; increased rate of VTE in TXA | TXA is recommended for “severely injured shocked patients” |
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