Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes: A Genotype-Phenotype Correlation Analysis
Table 2
Comparisons of mean BPDE-induced apoptosis capacity in
apparently normal primary lymphocytes by the genotypes of selected apoptotic genes.
Variable
No. (%)
AC (mean ± SD)
P
P
Intrinsic pathway
p53 R72P
RR
91 (53.5)
Ref.
RP
65 (38.2)
.143
PP
14 (8.2)
.067
.016
p53 intron 3
16-bpdel/del
134 (78.8)
Ref.
16-bpdel/ins
34 (20.0)
.993
16-bpins/ins
2 (1.2)
.027
.274
p53 intron 6
GG
135 (79.4)
Ref.
GA
33 (19.4)
0.495
AA
2 (1.2)
.021
.099
Bcl-2 −938C>A
CC
53 (31.2)
Ref.
CA
76 (44.7)
.087
AA
41 (24.1)
.046
.037
BAX –248G>A
GG
144 (84.7)
Ref.
GA
25 (14.7)
.613
AA
1 (0.6)
84.85
—
CASP9 Q221R
QQ
53 (31.2)
Ref.
QR
75 (44.1)
.571
RR
42 (24.7)
.620
.704
Extrinsic pathway
DR4 T209R
TT
52 (30.6)
Ref.
TR
75 (44.1)
.160
RR
43 (25.3)
.497
.485
Fas –1377G>A
GG
126 (74.1)
Ref.
GA
42 (24.7)
.248
AA
2 (1.2)
.396
.182
Fas –670A>G
AA
43 (25.3)
Ref.
GA
86 (50.6)
.472
GG
41 (24.1)
.058
.085
FasL –844T>C
CC
79 (46.5)
Ref.
CT
74 (43.5)
.245
TT
17 (10.0)
.629
.464
CASP8 D302H
DD
127 (74.7)
Ref.
DH
38 (22.4)
.802
HH
5 (2.9)
.162
.389
CASP10 I522L
II
54 (31.8)
Ref.
IL
74 (43.5)
.430
LL
42 (24.7)
.046
.046
Effective CASPs
CASP3 –1337C>G
CC
107 (62.9)
Ref.
CG
51 (30.0)
.970
GG
12 (7.1)
.388
.516
CASP7 D255E
DD
95 (55.9)
Ref.
DE
68 (40.0)
.516
EE
7 (4.1)
.829
.801
Two-sided
Student t-test.Trend test
obtained from general linear regress model with adjustment for age and sex.
