Risk of Late Mortality and Second Malignant Neoplasms among 5-Year Survivors of Young Adult Cancer: A Report of the Childhood, Adolescent, and Young Adult Cancer Survivors Research Program

Table 3

Second malignant neoplasm, standard incidence ratio, and absolute excess risk of young adult cancer by sex^f.

	Entire cohort (𝑁=1248)					Male (𝑁=589)				Female (𝑁=659)
	Obs^a	Exp^b	SMR^c	95% CI^d	AER^e	Obs^a	SIR^b	95% CI^c	AER^d	Obs^a	SIR^b	95% CI^c	AER^d
Overall	62	21	3.0	𝟐.𝟑−𝟑.𝟖^∗	1.9	25	3.6	𝟐.𝟑−𝟓.𝟑^∗	1.9	37	2.7	𝟏.𝟗−𝟑.𝟕^∗	2.0
Type of original cancer
Lymphoma	31	4.4	7.0	𝟒.𝟕−𝟗.𝟗^∗	5.3	12	6.5	𝟑.𝟒−𝟏𝟏.𝟒^∗	3.9	19	7.3	𝟒.𝟒−𝟏𝟏.𝟒^∗	6.7
Germ cell tumor	7	2.3	3.1	𝟏.𝟐−𝟔.𝟑^∗	1.6	7	3.7	𝟏.𝟓−𝟕.𝟔^∗	1.9	0	0	N/A	N/A
Melanoma	6	3.4	1.7	0.6–3.8	0.7	0	0	N/A	N/A	6	2.4	0.9–5.3	1.5
Carcinomas	12	7.9	1.5	0.8–2.7	0.6	<5	2.7	0.6–7.9	1.4	9	1.3	0.6–2.5	0.4
Others^e	6	2.9	2.1	0.8–4.5	1.0	<5	2.4	0.5–7.1	1.0	<5	1.5	0.3–4.3	0.6
Follow-up time (years)
5–19 years	30	2.6	11.6	𝟕.𝟗−𝟏𝟔.𝟔^∗	5.5	12	11.2	𝟓.𝟖−𝟏𝟗.𝟔^∗	4.7	18	12	𝟕.𝟏−𝟏𝟖.𝟗^∗	6.2
+20 years	32	18.4	1.7	𝟏.𝟐−𝟐.𝟓^∗	0.8	13	2.2	𝟏.𝟐−𝟑.𝟕^∗	0.9	19	1.5	0.9–2.4	0.7
Diagnosis period
1970–1979	32	12.7	2.5	𝟏.𝟕−𝟑.𝟓^∗	2.0	16	4.4	𝟐.𝟓−𝟕.𝟐^∗	3.3	16	1.8	𝟏.𝟎−𝟐.𝟗^∗	1.2
1980–1989	24	6.7	3.6	𝟐.𝟑−𝟓.𝟑^∗	1.9	7	2.5	𝟏.𝟎−𝟓.𝟐^∗	0.9	17	4.3	𝟐.𝟓−𝟔.𝟗^∗	2.9
1990–1995	6	1.5	4.0	𝟏.𝟓−𝟖.𝟕^∗	1.5	<5	3.1	0.4–11.3	0.9	<5	4.7	𝟏.𝟑−𝟏𝟏.𝟗^∗	1.9
Having chemotherapy
Yes	24	3.8	6.3	𝟒.𝟏−𝟗.𝟒^∗	3.9	10	5.1	𝟐.𝟒−𝟗.𝟑^∗	2.6	14	7.7	𝟒.𝟐−𝟏𝟐.𝟗^∗	5.9
No	29	9.4	3.1	𝟐.𝟏−𝟒.𝟒^∗	2.1	11	3.3	𝟏.𝟔−𝟓.𝟗^∗	1.7	18	3.0	𝟏.𝟖−𝟒.𝟕^∗	2.4
Missing	9	7.8	1.2	0.5–2.2	0.2	<5	2.4	0.7–6.0	1.1	5	0.8	0.3–1.9	−0.2
Having radiation
Yes	35	6.2	5.7	𝟒−𝟕.𝟗^∗	4.5	14	5.2	𝟐.𝟗−𝟖.𝟖^∗	3.2	21	6.0	𝟑.𝟕−𝟗.𝟐^∗	6.0
No	27	14.8	1.8	𝟏.𝟐−𝟐.𝟕^∗	0.8	11	2.5	𝟏.𝟑−𝟒.𝟓^∗	1.1	16	1.5	0.9–2.5	0.6
Having surgery
Yes	35	9.4	3.7	𝟐.𝟔−𝟓.𝟐^∗	2.5	12	3.1	𝟏.𝟔−𝟓.𝟒^∗	1.5	23	4.2	𝟐.𝟔−𝟔.𝟐^∗	3.5
No	19	3.8	5.0	𝟑.𝟎−𝟕.𝟖^∗	3.5	10	6.7	𝟑.𝟐−𝟏𝟐.𝟑^∗	4.0	9	3.9	𝟏.𝟖−𝟕.𝟑^∗	3.1
Missing	8	7.7	1.0	0.5–2.0	0.1	<5	1.8	0.4–5.2	0.6	5	0.8	0.3–1.9	−0.2
Major types of SMN
Digestive system	10	2	4.9	𝟐.𝟒−𝟗.𝟏^∗	0.4	9	9.7	𝟒.𝟒−𝟏𝟖.𝟑^∗	0.8	<5	0.9	0–5.1	0.0
Respiratory system	7	1.1	6.2	𝟐.𝟓−𝟏𝟐.𝟖^∗	0.3	<5	7.0	𝟏.𝟒−𝟐𝟎.𝟓^∗	0.3	<5	5.7	𝟏.𝟔−𝟏𝟒.𝟔^∗	0.3
Breast	18	5.1	3.6	𝟐.𝟏−𝟓.𝟔^∗	0.6	N/A	N/A	N/A	N/A	18	3.6	𝟐.𝟏−𝟓.𝟔^∗	1.1
Endocrine glands	6	1.2	5.0	𝟏.𝟖−𝟏𝟎.𝟖^∗	0.2	<5	9.2	𝟏.𝟏−𝟑𝟑.𝟐^∗	0.2	<5	4.0	𝟏.𝟏−𝟏𝟎.𝟑^∗	0.3
Others	21	11.5	1.8	𝟏.𝟏−𝟐.𝟖^∗	0.1	11	2.0	𝟏.𝟎−𝟑.𝟔^∗	0.1	10	1.6	0.8–3.0	0.0

^∗𝑃<0.05.
^aObs: number of observed deaths.
^bSMR: standardized mortality ratio.
^c95% CI: 95% confidence interval.
^dAER: absolute excess risk, per 1,000 years at risk.
^eOther types of original cancers include leukemia, central nervous system tumor, bone tumor, soft tissue sarcoma, and miscellaneous-specified tumor.
^fTo protect confidentiality, all counts less than five are not specified.