Table of Contents Author Guidelines Submit a Manuscript
Journal of Cancer Epidemiology
Volume 2012 (2012), Article ID 191090, 8 pages
http://dx.doi.org/10.1155/2012/191090
Research Article

Predictors of Immunosuppressive Regulatory T Lymphocytes in Healthy Women

1Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
2Department of Flow and Image Cytometry, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
3Department of Gynecology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
4School of Medicine, Stony Brook University, Stony Brook, NY 11790, USA

Received 24 April 2012; Accepted 12 July 2012

Academic Editor: L. A. Liotta

Copyright © 2012 Shalaka S. Hampras et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Lindley, C. M. Dayan, A. Bishop, B. O. Roep, M. Peatman, and T. I. M. Tree, “Defective suppressor function in CD4+CD25+ T-cells from patients with type 1 diabetes,” Diabetes, vol. 54, no. 1, pp. 92–99, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Huan, N. Culbertson, L. Spencer et al., “Decreased FOXP3 levels in multiple sclerosis patients,” Journal of Neuroscience Research, vol. 81, no. 1, pp. 45–52, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Venken, N. Hellings, T. Broekmans, K. Hensen, J. L. Rummens, and P. Stinissen, “Natural naive CD4+CD25+CD127low regulatory T cell (Treg) development and function are disturbed in multiple sclerosis patients: recovery of memory Treg homeostasis during disease progression,” Journal of Immunology, vol. 180, no. 9, pp. 6411–6420, 2008. View at Google Scholar · View at Scopus
  4. S. C. Lin, K. H. Chen, C. H. Lin, C. C. Kuo, Q. D. Ling, and C. H. Chan, “The quantitative analysis of peripheral blood FOXP3-expressing T cells in systemic lupus erythematosus and rheumatoid arthritis patients,” European Journal of Clinical Investigation, vol. 37, no. 12, pp. 987–996, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. C. A. Lawson, A. K. Brown, V. Bejarano et al., “Early rheumatoid arthritis is associated with a deficit in the CD4+CD25high regulatory T cell population in peripheral blood,” Rheumatology, vol. 45, no. 10, pp. 1210–1217, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. S. N. Ukena, S. Velaga, R. Geffers et al., “Human regulatory T cells in allogeneic stem cell transplantation,” Blood, vol. 118, no. 13, pp. e82–e92, 2011. View at Google Scholar
  7. P. A. Taylor, R. J. Noelle, and B. R. Blazar, “CD4+CD25+ immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade,” Journal of Experimental Medicine, vol. 193, no. 11, pp. 1311–1317, 2001. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Mjösberg, G. Berg, J. Ernerudh, and C. Ekerfelt, “CD4+ CD25+ regulatory T cells in human pregnancy: development of a Treg-MLC-ELISPOT suppression assay and indications of paternal specific Tregs,” Immunology, vol. 120, no. 4, pp. 456–466, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. P. A. Antony, C. M. Paulos, M. Ahmadzadeh et al., “Interleukin-2-dependent mechanisms of tolerance and immunity in vivo,” Journal of Immunology, vol. 176, no. 9, pp. 5255–5266, 2006. View at Google Scholar · View at Scopus
  10. S. Sakaguchi, “Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses,” Annual Review of Immunology, vol. 22, pp. 531–562, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. M. Asano, M. Toda, N. Sakaguchi, and S. Sakaguchi, “Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation,” Journal of Experimental Medicine, vol. 184, no. 2, pp. 387–396, 1996. View at Google Scholar · View at Scopus
  12. B. Mukherji, A. Guha, N. G. Chakraborty et al., “Clonal analysis of cytotoxic and regulatory T cell responses against human melanoma,” Journal of Experimental Medicine, vol. 169, no. 6, pp. 1961–1976, 1989. View at Google Scholar · View at Scopus
  13. B. Mukherji, A. L. Nashed, A. Guha, and M. T. Ergin, “Regulation of cellular immune response against autologous human melanoma. II. Mechanism of induction and specificity of suppression,” Journal of Immunology, vol. 136, no. 5, pp. 1893–1898, 1986. View at Google Scholar · View at Scopus
  14. B. Mukherji, S. A. Wilhelm, A. Guha, and M. T. Ergin, “Regulation of cellular immune response against autologous human melanoma. I. Evidence for cell-mediated suppression of in vitro cytotoxic immune response,” Journal of Immunology, vol. 136, no. 5, pp. 1888–1892, 1986. View at Google Scholar · View at Scopus
  15. U. K. Liyanage, T. T. Moore, H. G. Joo et al., “Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma,” Journal of Immunology, vol. 169, no. 5, pp. 2756–2761, 2002. View at Google Scholar · View at Scopus
  16. B. Barnett, I. Kryczek, P. Cheng, W. Zou, and T. J. Curiel, “Regulatory T cells in ovarian cancer: biology and therapeutic potential,” American Journal of Reproductive Immunology, vol. 54, no. 6, pp. 369–377, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. K. Chikamatsu, K. Sakakura, T. L. Whiteside, and N. Furuya, “Relationships between regulatory T cells and CD8+ effector populations in patients with squamous cell carcinoma of the head and neck,” Head and Neck, vol. 29, no. 2, pp. 120–127, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. M. Miller, K. Lundberg, V. Özenci et al., “CD4+CD25high T cells are enriched in the tumor and peripheral blood of prostate cancer patients,” Journal of Immunology, vol. 177, no. 10, pp. 7398–7405, 2006. View at Google Scholar · View at Scopus
  19. F. Meloni, M. Morosini, N. Solari et al., “Foxp3 expressing CD4+ CD25+ and CD8+CD28- T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma,” Human Immunology, vol. 67, no. 1-2, pp. 1–12, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. B. Karagoz, O. Bilgi, M. Gümüs et al., “CD8+CD28- cells and CD4+CD25+ regulatory T cells in the peripheral blood of advanced stage lung cancer patients,” Medical Oncology, vol. 27, no. 1, pp. 29–33, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Sasada, M. Kimura, Y. Yoshida, M. Kanai, and A. Takabayashi, “CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression,” Cancer, vol. 98, no. 5, pp. 1089–1099, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. C. B. Ambrosone, M. K. Nesline, and W. Davis, “Establishing a cancer center data bank and biorepository for multidisciplinary research,” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 9, pp. 1575–1577, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Grant, K. Bourcier, S. Wallace et al., “Validated protocol for FoxP3 reveals increased expression in type 1 diabetes patients,” Cytometry B, vol. 76, no. 2, pp. 69–78, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Sakaguchi, T. Yamaguchi, T. Nomura, and M. Ono, “Regulatory T cells and immune tolerance,” Cell, vol. 133, no. 5, pp. 775–787, 2008. View at Publisher · View at Google Scholar · View at Scopus
  25. I. Kryczek, R. Liu, G. Wang et al., “FOXP3 defines regulatory t cells in human tumor and autoimmune disease,” Cancer Research, vol. 69, no. 9, pp. 3995–4000, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. A. M. Wolf, D. Wolf, M. Steurer, G. Gastl, E. Gunsilius, and B. Grubeck-Loebenstein, “Increase of regulatory T cells in the peripheral blood of cancer patients,” Clinical Cancer Research, vol. 9, no. 2, pp. 606–612, 2003. View at Google Scholar · View at Scopus
  27. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda, “Immunologic self-tolerance maintained by activated T cells expressing IL- 2 receptor α-chains (CD25): breakdown of a single mechanism of self- tolerance causes various autoimmune diseases,” Journal of Immunology, vol. 155, no. 3, pp. 1151–1164, 1995. View at Google Scholar · View at Scopus
  28. S. Sakaguchi, T. Takahashi, and Y. Nishizuka, “Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirements of Lyt-1 effector cells of oocytes damage after adoptive transfer,” Journal of Experimental Medicine, vol. 156, no. 6, pp. 1565–1576, 1982. View at Google Scholar · View at Scopus
  29. S. Sakaguchi, T. Takahashi, and Y. Nishizuka, “Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirements of Lyt-1 cells in normal female mice for the prevention of oophoritis,” Journal of Experimental Medicine, vol. 156, no. 6, pp. 1577–1586, 1982. View at Google Scholar · View at Scopus
  30. R. Gregg, C. M. Smith, F. J. Clark et al., “The number of human peripheral blood CD4+ CD25high regulatory T cells increases with age,” Clinical and Experimental Immunology, vol. 140, no. 3, pp. 540–546, 2005. View at Publisher · View at Google Scholar · View at Scopus
  31. B. Barceló, J. Pons, J. M. Ferrer, J. Sauleda, A. Fuster, and A. G. N. Agustí, “Phenotypic characterisation of T-lymphocytes in COPD: abnormal CD4+CD25+ regulatory T-lymphocyte response to tobacco smoking,” European Respiratory Journal, vol. 31, no. 3, pp. 555–562, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. C.-A. Brandsma, M. N. Hylkema, B. W. A. van der Strate et al., “Heme oxygenase-1 prevents smoke induced B-cell infiltrates: a role for regulatory T cells?” Respiratory Research, vol. 9, article 17, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. U. Costabel, K. J. Bross, and C. Reuter, “Alterations in immunoregulatory T-cell subsets in cigarette smokers. A phenotypic analysis of bronchoalveolar and blood lymphocytes,” Chest, vol. 90, no. 1, pp. 39–44, 1986. View at Google Scholar · View at Scopus
  34. R. Vassallo, K. Tamada, J. S. Lau, P. R. Kroening, and L. Chen, “Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming,” Journal of Immunology, vol. 175, no. 4, pp. 2684–2691, 2005. View at Google Scholar · View at Scopus
  35. X. L. Yuan, L. Chen, M. X. Li et al., “Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner,” Clinical Immunology, vol. 134, no. 3, pp. 277–288, 2010. View at Publisher · View at Google Scholar · View at Scopus
  36. K. Atarashi, T. Mori, R. Yoshiki, K. Kabashima, H. Kuma, and Y. Tokura, “Skin application of ketoprofen systemically suppresses contact hypersensitivity by inducing CD4+ CD25+ regulatory T cells,” Journal of Dermatological Science, vol. 53, no. 3, pp. 216–221, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. L. Arruvito, M. Sanz, A. H. Banham, and L. Fainboim, “Expansion of CD4+CD25+ and FOXP3+ regulatory T cells during the follicular phase of the menstrual cycle: implications for human reproduction,” Journal of Immunology, vol. 178, no. 4, pp. 2572–2578, 2007. View at Google Scholar · View at Scopus
  38. G. A. Prieto and Y. Rosenstein, “Oestradiol potentiates the suppressive function of human CD4+ CD25+ regulatory T cells by promoting their proliferation,” Immunology, vol. 118, no. 1, pp. 58–65, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. J. Womack, P. C. Tien, J. Feldman et al., “Obesity and immune cell counts in women,” Metabolism, vol. 56, no. 7, pp. 998–1004, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Zeyda, J. Huber, G. Prager, and T. M. Stulnig, “Inflammation correlates with markers of T-cell subsets including regulatory T cells in adipose tissue from obese patients,” Obesity, vol. 19, no. 4, pp. 743–748, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. V. De Rosa, C. Procaccini, G. Calì et al., “A key role of leptin in the control of regulatory T cell proliferation,” Immunity, vol. 26, no. 2, pp. 241–255, 2007. View at Publisher · View at Google Scholar · View at Scopus
  42. G. Matarese, C. Procaccini, V. De Rosa, T. L. Horvath, and A. La Cava, “Regulatory T cells in obesity: the leptin connection,” Trends in Molecular Medicine, vol. 16, no. 6, pp. 247–256, 2010. View at Publisher · View at Google Scholar · View at Scopus
  43. E. Lahelma, P. Martikainen, M. Laaksonen, and A. Aittomäki, “Pathways between socioeconomic determinants of health,” Journal of Epidemiology and Community Health, vol. 58, no. 4, pp. 327–332, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. E. Ammirati, D. Cianflone, M. Banfi et al., “Circulating CD4+CD25hiCD127lo regulatory T-cell levels do not reflect the extent or severity of carotid and coronary atherosclerosis,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 9, pp. 1832–1841, 2010. View at Publisher · View at Google Scholar · View at Scopus