The Interaction between Pesticide Use and Genetic Variants Involved in Lipid Metabolism on Prostate Cancer Risk

Table 3

Associations between intensity-weighted lifetime days of pesticide use and prostate cancer risk by lipid metabolism variants where FDR 𝑃 interaction <0.05¹.

Pesticide

Gene

SNP

SNP region

Genotype

Non-exposed

Low exposed

High exposed

Exposure trend

𝑃 interaction^2

FDR 𝑃 interaction^1,2

Case/control

Case/control

OR^2

(95%CI)^2

𝑃^2

Case/control

OR^2

(95%CI)^22

𝑃^2

OR^2

(95%CI)^2

𝑃^2

Insecticides

Terbufos

ALOXE3; (epidermis-type lip oxygenase 3)

rs3027208

IVS7+369G>A

CC; CT+TT

307/576; 99/227

REF; REF

102/195; 43/55

0.99; 1.86

(0.74–1.31); (1.16–2.99)

0.93; 0.01

81/188; 50/60

0.81; 2.00

(0.60–1.10); (1.28–3.15)

0.18; 0.00

0.91; 1.45

(0.79–1.05); (1.16–1.81)

0.22; 0.001

0.001

0.01

SEC14L2; (SEC14-like protein 2)

rs2072159

IVS2−93G>A

GG; AG+AA

201/457; 204/342

REF; REF

83/139; 61/108

1.38; 0.97

(0.99–1.92); (0.67–1.40)

0.05; 0.88

82/132; 47/115

1.43; 0.70

(1.03–1.99); (0.48–1.03)

0.03; 0.07

1.21; 0.86

(1.03–1.42); (0.71–1.03)

0.02; 0.10

0.003

0.01

ADIPOR1; (adiponectin receptor 1)

rs12733285

IVS1−1748G>A

CC; CT+TT

183/421; 223/372

REF; REF

74/123; 70/126

1.39; 0.96

(0.98–1.96); (0.68–1.35)

0.07; 0.80

80/131; 51/117

1.43; 0.75

(1.02–1.99); (0.52–1.10)

0.04; 0.14

1.21; 0.88

(1.03–1.43); (0.74–1.05)

0.02; 0.16

0.01

0.02

Fonofos

ABCG8; (ATP-binding cassette subfamily G member 8)

rs4953028

IVS10+205G>A

GG; AG+AA

141/345; 368/644

REF; REF

26/38; 59/120

1.73; 0.89

(0.99–3.00); (0.63–1.25)

0.05; 0.50

36/46; 56/106

1.94; 0.95

(1.17–3.20); (0.66–1.36)

0.01; 0.77

1.43; 0.96

(1.12–1.82); (0.81–1.14)

0.004; 0.63

0.005

0.02

Carbofuran

A4GALT; (lactosylceramide 4-alpha-galactosyltransferase)

rs8136914

IVS1+4129T>C

AA; AG+GG

210/477; 222/378

REF; REF

69/128; 54/93

1.22; 1.01

(0.87–1.71); (0.69–1.47)

0.25; 0.96

72/115; 48/107

1.43; 0.76

(1.02–2.00); (0.52–1.12)

0.04; 0.17

1.20; 0.89

(1.02–1.41); (0.75–1.07)

0.03; 0.22

0.02

0.03

LDLR; (low-density lipoprotein receptor)

rs8110695

IVS1−4369T>A

TT; AT+AA

285/509; 145/342

REF; REF

76/132; 47/92

1.04; 1.17

(0.75–1.43); (0.78–1.76)

0.82; 0.44

64/138; 55/83

0.83; 1.58

(0.60–1.16); (1.06–2.33)

0.27; 0.02

0.93; 1.24

(0.80–1.09); (1.03–1.51)

0.36; 0.02

0.02

0.04

Herbicides

EPTC

ALOX15; (arachidonate 15-lipoxygenase)

rs916055

Ex14+241T>C

AA; AG+GG

242/433; 274/592

REF; REF

34/45; 45/70

1.38; 1.47

(0.85–2.23); (0.98–2.22)

0.19; 0.06

18/58; 42/58

0.56; 1.63

(0.32–0.99); (1.06–2.50)

0.05; 0.02

0.85; 1.31

(0.67–1.09); (1.07–1.60)

0.19; 0.01

0.01

0.01

Petroleum iil/distillates

ALOX5; (arachidonate 5-lipoxygenase)

rs7099684

IVS12−61T>C

TT; AT+AA

281/602; 200/346

REF; REF

33/63; 19/36

1.19; 0.91

(0.76–1.86); (0.51–1.63)

0.45; 0.76

43/60; 14/41

1.56; 0.60

(1.03–2.38); (0.32–1.13)

0.04; 0.12

1.24; 0.80

(1.02–1.51); (0.60–1.07)

0.03; 0.13

0.02

0.02

LRP1; (low-density lipoprotein receptor-related protein 1)

rs1800159

IVS62+86A>G

GG; AG+AA

229/477; 258/484

REF; REF

18/51; 34/52

0.74; 1.26

(0.42–1.31); (0.80–2.00)

0.31; 0.32

20/58; 41/45

0.72; 1.76

(0.42–1.23); (1.12–2.77)

0.23; 0.01

0.83; 1.32

(0.65–1.07); (1.07–1.63)

0.15; 0.01

0.01

0.03

rs7956957

IVS78−51C>G

GG; CG+CC

209/417; 279/547

REF; REF

14/44; 38/59

0.66; 1.32

(0.35–1.23); (0.85–2.03)

0.19; 0.22

17/46; 44/57

0.75; 1.57

(0.42–1.34); (1.03–2.40)

0.33; 0.04

0.83; 1.26

(0.63–1.09); (1.04–1.54)

0.17; 0.02

0.02

0.03

rs6581128

IVS42−916C>A

CC; AC+AA

227/452; 261/509

REF; REF

21/49; 31/54

0.87; 1.17

(0.51–1.49); (0.73–1.87)

0.61; 0.52

18/51; 43/50

0.70; 1.73

(0.40–1.23); (1.12–2.68)

0.22; 0.01

0.84; 1.29

(0.65–1.09); (1.05–1.59)

0.20; 0.01

0.02

0.03

rs7978567

IVS67−220C>T

CC; CT+TT

219/437; 268/527

REF; REF

16/48; 36/55

0.69; 1.34

(0.38–1.25); (0.86–2.10)

0.22; 0.20

20/49; 41/54

0.83; 1.56

(0.48–1.43); (1.01–2.41)

0.49; 0.05

0.87; 1.26

(0.67–1.13); (1.03–1.55)

0.29; 0.02

0.03

0.04

ACSL5; (acyl-CoA synthetase long hain)

rs12098576

IVS6−530C>A

GG; GT+TT

379/715; 109/249

REF; REF

35/71; 17/32

0.96; 1.20

(0.63–1.47); (0.64–2.26)

0.86; 0.57

40/84; 21/19

0.93; 2.54

(0.62–1.39); (1.31–4.92)

0.72; 0.01

0.96; 1.51

(0.80–1.16); (1.11–2.05)

0.70; 0.01

0.01

0.04

rs876873

IVS6−530C>A

TT; CT+CC

369/691; 119/269

REF; REF

32/69; 20/34

0.90; 1.33

(0.58–1.39); (0.73–2.41)

0.62; 0.35

38/80; 23/21

0.93; 2.46

(0.61–1.39); (1.31–4.63)

0.71; 0.01

0.95; 1.52

(0.79–1.15); (1.14–2.04)

0.61; 0.005

0.01

0.04

Glyphosate

ALOX5AP; (arachidonate 5-lipoxygenase-activating protein)

rs9579645

IVS1+694A>C

AA; AC+CC

151/241; 31/91

REF; REF

227/433; 48/109

0.84; 1.25

(0.64–1.09); (0.73–2.16)

0.18; 0.42

200/410; 71/120

0.78; 1.74

(0.59–1.02); (1.03–2.93)

0.07; 0.04

0.89; 1.33

(0.77–1.02); (1.03–1.72)

0.08; 0.03

0.004

0.02

Atrazine

LDLR; (low-density lipoprotein receptor)

rs8110695

IVS1−4369T>A

TT; AT+AA

128/223; 60/150

REF; REF

181/307; 92/207

1.04; 1.11

(0.78–1.40); (0.75–1.66)

0.79; 0.59

154/315; 117/199

0.86; 1.49

(0.64–1.16); (1.01–2.19)

0.33; 0.04

0.92; 1.23

(0.79–1.07); (1.02–1.49)

0.27; 0.03

0.02

0.03

LRP1; (low-density lipoprotein receptor-related protein 1)

rs1800159

IVS62+86A>G

GG; AG+AA

91/173; 98/202

REF; REF

117/261; 156/254

0.85; 1.32

(0.60–1.19); (0.95–1.82)

0.34; 0.10

108/273; 165/241

0.74; 1.46

(0.52–1.05); (1.06–2.02)

0.09; 0.02

0.86; 1.20

(0.73–1.02); (1.02–1.40)

0.09; 0.02

0.01

0.04

¹Accounts for the number of SNPs per gene.
²Risk estimates adjusted for age and state.