Table of Contents Author Guidelines Submit a Manuscript
Journal of Cancer Epidemiology
Volume 2012, Article ID 708936, 9 pages
http://dx.doi.org/10.1155/2012/708936
Research Article

Uptake and Tolerance of Chemotherapy in Elderly Patients with Small Cell Lung Cancer and Impact on Survival

1School of Public Health, University of Alberta, Edmonton, Alberta, Canada T6G 1C9
2Princess Noorah Oncology Centre, King Abdulaziz Medical City, Jeddah, Saudi Arabia
3Cancer Care, Alberta Health Services, Edmonton, Alberta, Canada T5J 3H1
4Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2

Received 8 August 2012; Revised 5 October 2012; Accepted 26 October 2012

Academic Editor: Frank Buntinx

Copyright © 2012 Stacey Fisher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward, and D. Forman, “Global cancer statistics,” CA Cancer Journal for Clinicians, vol. 61, no. 2, pp. 69–90, 2011. View at Publisher · View at Google Scholar · View at Scopus
  2. G. R. Simon and A. Turrisi, “Management of small cell lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition),” Chest, vol. 132, supplement 3, pp. S324–S339, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. D. M. Jackman and B. E. Johnson, “Small-cell lung cancer,” The Lancet, vol. 366, no. 9494, pp. 1385–1396, 2005. View at Publisher · View at Google Scholar · View at Scopus
  4. A. Kurup and N. H. Hanna, “Treatment of small cell lung cancer,” Critical Reviews in Oncology/Hematology, vol. 52, no. 2, pp. 117–126, 2004. View at Publisher · View at Google Scholar · View at Scopus
  5. Canadian Cancer Society's Steering Committee on Cancer Statistics, Canadian Cancer Statistics 2012, Canadian Cancer Society, Toronto, ON, Canada, 2012.
  6. A. G. Pallis, F. A. Shepherd, D. Lacombe, and C. Gridelli, “Treatment of small-cell lung cancer in elderly patients,” Cancer, vol. 116, no. 5, pp. 1192–1200, 2010. View at Publisher · View at Google Scholar · View at Scopus
  7. J. J. S. Ludbrook, P. T. Truong, M. V. MacNeil et al., “Do age and comorbidity impact treatment allocation and outcomes in limited stage small-cell lung cancer? A community-based population analysis,” International Journal of Radiation Oncology Biology Physics, vol. 55, no. 5, pp. 1321–1330, 2003. View at Publisher · View at Google Scholar · View at Scopus
  8. M. L. G. Janssen-Heijnen, R. M. Schipper, P. P. A. Razenberg, M. A. Crommelin, and J. W. W. Coebergh, “Prevalence of co-morbidity in lung cancer patients and its relationship with treatment: a population-based study,” Lung Cancer, vol. 21, no. 2, pp. 105–113, 1998. View at Publisher · View at Google Scholar · View at Scopus
  9. L. F. Hutchins, J. M. Unger, J. J. Crowley, C. A. Coltman, and K. S. Albain, “Underrepresentation of patients 65 years of age or older in cancer- treatment trials,” New England Journal of Medicine, vol. 341, no. 27, pp. 2061–2067, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. L. Balducci, “Geriatric oncology: challenges for the new century,” European Journal of Cancer, vol. 36, no. 14, pp. 1741–1754, 2000. View at Publisher · View at Google Scholar · View at Scopus
  11. K. W. L. Yee, J. L. Pater, L. Pho, B. Zee, and L. L. Siu, “Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier?” Journal of Clinical Oncology, vol. 21, no. 8, pp. 1618–1623, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. D. H. Johnson, “Treatment of the elderly patient with small-cell lung cancer,” Chest, vol. 103, no. 1, 1992. View at Google Scholar · View at Scopus
  13. S. M. Lichtman, J. A. Skirvin, and S. Vemulapalli, “Pharmacology of antineoplastic agents in older cancer patients,” Critical Reviews in Oncology/Hematology, vol. 46, no. 2, pp. 101–114, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. R. Yancik, R. J. Havlik, M. N. Wesley et al., “Cancer and comorbidity in older patients: a descriptive profile,” Annals of Epidemiology, vol. 6, no. 5, pp. 399–412, 1996. View at Publisher · View at Google Scholar · View at Scopus
  15. L. Z. Rubenstein, K. R. Josephson, M. Nichol-Seamons, and A. S. Robbins, “Comprehensive health screening of well elderly adults: an analysis of a community program,” Journals of Gerontology, vol. 41, no. 3, pp. 342–352, 1986. View at Google Scholar · View at Scopus
  16. M. Shields and L. Martel, “Healthy living among seniors,” Health Report, vol. 16, pp. S7–S20, 2006. View at Google Scholar · View at Scopus
  17. M. P. Lebitasy, G. Hédelin, A. Purohit, L. Moreau, F. Klinzig, and E. Quoix, “Progress in the management and outcome of small-cell lung cancer in a French region from 1981 to 1994,” British Journal of Cancer, vol. 85, no. 6, pp. 808–815, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. M. Weinmann, B. Jeremic, M. Bamberg, and C. Bokemeyer, “Treatment of lung cancer in elderly part II: small cell lung cancer,” Lung Cancer, vol. 40, no. 1, pp. 1–16, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. S. Monfardini, L. Ferrucci, L. Fratino et al., “Validation of a multidimensional evaluation scale for use in elderly cancer patients,” Cancer, vol. 77, no. 2, pp. 395–401, 1996. View at Publisher · View at Google Scholar
  20. Statistics Canada, “Population, urban and rural, by province and territory (Alberta table),” Population, urban and rural, by province and territory, Population estimates and projection, Population and democracy, Summary Tables , 2006, last updated September 22, 2009, http://www.isesd.cv.ic.ac.uk/, 2012.
  21. Fritz, C. Percy, A. Jack et al., Eds., International Classification of Diseases For Oncology, World Health Organization, Geneva, Switzerland, 3rd edition, 2000.
  22. T. C. Tucker, H. L. Howe, and H. K. Weir, “Certification for population-based cancer registries,” Journal of Registry Management, vol. 26, pp. 24–27, 1999. View at Google Scholar
  23. K. Shibata, K. Kasahara, Y. Nakatsumi, T. Bando, M. Fuigmura, and T. Matsuda, “Carboplatin plus etoposide in the treatment of small cell lung cancer,” Lung Cancer, vol. 18, supplement 1, p. 54, 1997. View at Google Scholar
  24. K. Matsui, N. Masuda, M. Fukuoka et al., “Phase II trial of carboplatin plus oral etoposide for elderly patients with small-cell lung cancer,” British Journal of Cancer, vol. 77, no. 11, pp. 1961–1965, 1998. View at Google Scholar · View at Scopus
  25. H. Okamoto, K. Watanabe, Y. Nishiwaki et al., “Phase II study of area under the plasma-concentration-versus-time curve- based carboplatin plus standard-dose intravenous etoposide in elderly patients with small-cell lung cancer,” Journal of Clinical Oncology, vol. 17, no. 11, pp. 3540–3545, 1999. View at Google Scholar · View at Scopus
  26. S. Larive, P. Bombaron, R. Riou et al., “Carboplatin-etoposide combination in small cell lung cancer patients older than 70 years: a phase II trial,” Lung Cancer, vol. 35, no. 1, pp. 1–7, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. M. L. G. Janssen-Heijnen, H. A. A. M. Maas, S. A. M. van de Schans, J. W. W. Coebergh, and H. J. M. Groen, “Chemotherapy in elderly small-cell lung cancer patients: yes we can, but should we do it?” Annals of Oncology, vol. 22, no. 4, pp. 821–826, 2011. View at Publisher · View at Google Scholar · View at Scopus
  28. M. L. G. Janssen-Heijnen, H. A. A. M. Maas, S. Siesling, C. C. E. Koning, J. W. W. Coebergh, and H. J. M. Groen, “Treatment and survival of patients with small-cell lung cancer: small steps forward, but not for patients >80,” Annals of Oncology, vol. 4, pp. 954–560, 2012. View at Google Scholar
  29. C. Gridelli, R. De Vivo, and S. Monfardini, “Management of small-cell lung cancer in the elderly,” Critical Reviews in Oncology/Hematology, vol. 41, no. 1, pp. 79–88, 2002. View at Publisher · View at Google Scholar · View at Scopus