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Journal of Cancer Epidemiology
Volume 2012, Article ID 957467, 9 pages
http://dx.doi.org/10.1155/2012/957467
Research Article

Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans

1Department of Obstetrics and Gynecology and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USA
2Department of Biology and Cancer Research Program, JLC-Biomedical/Biotechnology Research Institute, North Carolina Central University, Durham, NC 27707, USA
3Center for Health Services Research in Primary Care and Department of Hematology/Oncology, Durham VA Medical Center, Durham, NC 27705, USA
4Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
5Department of Surgery, Durham VA Medical Center, Durham, NC 27705, USA
6Department of Community and Family Medicine and Program of Cancer Detection, Prevention and Control, Duke University School of Medicine, Durham, NC 27710, USA
7Duke Prostate Center, Division of Urology, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
8Institute for Genome Sciences & Policy and Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27708, USA
9Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA
10Department of Community and Family Medicine, Duke University School of Medicine, P.O. Box 104006, Durham, NC 27710, USA

Received 24 April 2012; Revised 17 June 2012; Accepted 21 June 2012

Academic Editor: T. L. Vaughan

Copyright © 2012 Adriana C. Vidal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Ferlay, H. R. Shin, F. Bray, D. Forman, C. Mathers, and D. M. Parkin, “Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008,” International Journal of Cancer, vol. 127, no. 12, pp. 2893–2917, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. H. Grönberg, “Prostate cancer epidemiology,” The Lancet, vol. 361, no. 9360, pp. 859–864, 2003. View at Publisher · View at Google Scholar · View at Scopus
  3. L. E. Johns and R. S. Houlston, “A systematic review and meta-analysis of familial prostate cancer risk,” BJU International, vol. 91, no. 9, pp. 789–794, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. C. Pelucchi, C. Galeone, R. Talamini et al., “Dietary folate and risk of prostate cancer in Italy,” Cancer Epidemiology Biomarkers and Prevention, vol. 14, no. 4, pp. 944–948, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J. C. Figueiredo, M. V. Grau, R. W. Haile et al., “Folic acid and risk of prostate cancer: results from a randomized clinical trial,” Journal of the National Cancer Institute, vol. 101, no. 6, pp. 432–435, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. J. Weinstein, T. J. Hartman, R. Stolzenberg-Solomon et al., “Null association between prostate cancer and serum folate, vitamin b 6, vitamin b12, and homocysteine,” Cancer Epidemiology Biomarkers and Prevention, vol. 12, no. 11, pp. 1271–1272, 2003. View at Google Scholar · View at Scopus
  7. B. R. Van Guelpen, S. M. Wirén, A. R. J. Bergh, G. Hallmans, P. E. Stattin, and J. Hultdin, “Polymorphisms of methylenetetrahydrofolate reductase and the risk of prostate cancer: a nested case-control study,” European Journal of Cancer Prevention, vol. 15, no. 1, pp. 46–50, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Hultdin, B. Van Guelpen, A. Bergh, G. Hallmans, and P. Stattin, “Plasma folate, vitamin B12, and homocysteine and prostate cancer risk: a prospective study,” International Journal of Cancer, vol. 113, no. 5, pp. 819–824, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Johansson, P. N. Appleby, N. E. Allen et al., “Circulating concentrations of folate and vitamin B12 in relation to prostate cancer risk: results from the European prospective investigation into cancer and nutrition study,” Cancer Epidemiology Biomarkers and Prevention, vol. 17, no. 2, pp. 279–285, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. T. Key, P. B. Silcocks, G. K. Davey, P. N. Appleby, and D. T. Bishop, “A case-control study of diet and prostate cancer,” British Journal of Cancer, vol. 76, no. 5, pp. 678–687, 1997. View at Google Scholar · View at Scopus
  11. H. D. Vlajinac, J. M. Marinković, M. D. Ilić, and N. I. Kocev, “Diet and prostate cancer: a case-control study,” European Journal of Cancer Part A, vol. 33, no. 1, pp. 101–107, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. V. L. Stevens, C. Rodriguez, A. L. Pavluck, M. L. McCullough, M. J. Thun, and E. E. Calle, “Folate nutrition and prostate cancer incidence in a large cohort of US men,” American Journal of Epidemiology, vol. 163, no. 11, pp. 989–996, 2006. View at Publisher · View at Google Scholar · View at Scopus
  13. S. J. Weinstein, R. Stolzenberg-Solomon, P. Pietinen, P. R. Taylor, J. Virtamo, and D. Albanes, “Dietary factors of one-carbon metabolism and prostate cancer risk,” American Journal of Clinical Nutrition, vol. 84, no. 4, pp. 929–935, 2006. View at Google Scholar · View at Scopus
  14. E. Rossi, J. Hung, J. P. Beilby, M. W. Knuiman, M. L. Divitini, and H. Bartholomew, “Folate levels and cancer morbidity and mortality: prospective cohort study from Busselton, Western Australia,” Annals of Epidemiology, vol. 16, no. 3, pp. 206–212, 2006. View at Publisher · View at Google Scholar · View at Scopus
  15. J. Shannon, E. Phoutrides, A. Palma et al., “Folate intake and prostate cancer risk: a case-control study,” Nutrition and Cancer, vol. 61, no. 5, pp. 617–628, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. J. Duthie, “Folic acid deficiency and cancer: mechanisms of DNA instability,” British Medical Bulletin, vol. 55, no. 3, pp. 578–592, 1999. View at Google Scholar · View at Scopus
  17. M. Fenech, “The role of folic acid and Vitamin B12 in genomic stability of human cells,” Mutation Research, vol. 475, no. 1-2, pp. 57–67, 2001. View at Publisher · View at Google Scholar · View at Scopus
  18. B. T. Heijmans, J. M. A. Boer, H. E. D. Suchiman et al., “A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer,” Cancer Research, vol. 63, no. 6, pp. 1249–1253, 2003. View at Google Scholar · View at Scopus
  19. S. J. Duthie, G. Horgan, B. de Roos et al., “Blood folate status and expression of proteins involved in immune function, inflammation, and coagulation: biochemical and proteomic changes in the plasma of humans in response to long-term synthetic folic acid supplementation,” Journal of Proteome Research, vol. 9, no. 4, pp. 1941–1950, 2010. View at Publisher · View at Google Scholar · View at Scopus
  20. P. A. Jones and S. B. Baylin, “The fundamental role of epigenetic events in cancer,” Nature Reviews Genetics, vol. 3, no. 6, pp. 415–428, 2002. View at Google Scholar · View at Scopus
  21. T. Keku, R. Millikan, K. Worley et al., “5,10-Methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites,” Cancer Epidemiology Biomarkers and Prevention, vol. 11, no. 12, pp. 1611–1621, 2002. View at Google Scholar · View at Scopus
  22. M. Lucock, “Science, medicine, and the future: is folic acid the ultimate functional food component for disease prevention?” British Medical Journal, vol. 328, no. 7433, pp. 211–214, 2004. View at Google Scholar · View at Scopus
  23. J. B. Mason, “Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons,” Nutrition Reviews, vol. 67, no. 4, pp. 206–212, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. S. M. Zhang, W. C. Willett, J. Selhub et al., “Plasma folate, vitamin B6, vitamin B12, homocysteine, and risk of breast cancer,” Journal of the National Cancer Institute, vol. 95, no. 5, pp. 373–380, 2003. View at Google Scholar · View at Scopus
  25. U. Ericson, S. Borgquist, M. I. L. Ivarsson et al., “Plasma folate concentrations are positively associated with risk of estrogen receptor β negative breast cancer in a Swedish nested case control study,” Journal of Nutrition, vol. 140, no. 9, pp. 1661–1668, 2010. View at Publisher · View at Google Scholar · View at Scopus
  26. B. F. Cole, J. A. Baron, R. S. Sandler et al., “Folic acid for the prevention of colorectal adenomas: a randomized clinical trial,” Journal of the American Medical Association, vol. 297, no. 21, pp. 2351–2359, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. C. M. Pfeiffer, S. P. Caudill, E. W. Gunter, J. Osterloh, and E. J. Sampson, “Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999–2000,” American Journal of Clinical Nutrition, vol. 82, no. 2, pp. 442–450, 2005. View at Google Scholar · View at Scopus
  28. E. A. Yetley, C. M. Pfeiffer, K. W. Phinney et al., “Biomarkers of folate status in NHANES: a roundtable summary1–6,” American Journal of Clinical Nutrition, vol. 94, no. 1, pp. 303S–312S, 2011. View at Publisher · View at Google Scholar · View at Scopus
  29. C. M. Ulrich, J. D. Potter, and N. Ulrich, “Folate supplementation: too much of a good thing?” Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 2, pp. 189–193, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. A. D. Smith, Y. I. Kim, and H. Refsum, “Is folic acid good for everyone?” American Journal of Clinical Nutrition, vol. 87, no. 3, pp. 517–533, 2008. View at Google Scholar · View at Scopus
  31. J. B. Mason, A. Dickstein, P. F. Jacques et al., “A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis,” Cancer Epidemiology Biomarkers and Prevention, vol. 16, no. 7, pp. 1325–1329, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. S. M. Collin, C. Metcalfe, L. Zuccolo et al., “Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis,” Cancer Epidemiology Biomarkers and Prevention, vol. 18, no. 9, pp. 2528–2539, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. J. A. Antonelli, L. W. Jones, L. L. Bañez et al., “Exercise and prostate cancer risk in a cohort of veterans undergoing prostate needle biopsy,” Journal of Urology, vol. 182, no. 5, pp. 2226–2231, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. C. D. Williams, B. M. Whitley, C. Hoyo et al., “A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer,” Nutrition Research, vol. 31, no. 1, pp. 1–8, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. J. A. Roebuck Jr., Anthropometric Methods: Designing To Fit the Human Body, Human Factor and Ergonomics Society, Santa Monica, Calif, USA, 1995.
  36. W. C. Willet, L. Sampson, M. J. Stampfer et al., “Reproducibility and validity of a semiquantitative food frequency questionnaire,” American Journal of Epidemiology, vol. 122, no. 1, pp. 51–65, 1985. View at Google Scholar
  37. C. F. Adams, Nutritive Value of American Foods, vol. 456, United States Department of Agriculture, 1975.
  38. R. M. Feeley, P. E. Criver, and B. K. Watt, “Cholesterol content of foods,” Journal of the American Dietetic Association, vol. 61, no. 2, pp. 134–149, 1972. View at Google Scholar
  39. P. J. McLaughlin and J. L. Weihrauch, “Vitamin E content of foods,” Journal of the American Dietetic Association, vol. 75, no. 6, pp. 647–665, 1979. View at Google Scholar · View at Scopus
  40. S. Bettuzzi, M. Brausi, F. Rizzi, G. Castagnetti, G. Peracchia, and A. Corti, “Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study,” Cancer Research, vol. 66, no. 2, pp. 1234–1240, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. P. M. Das and R. Singal, “DNA methylation and cancer,” Journal of Clinical Oncology, vol. 22, no. 22, pp. 4632–4642, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. W. H. Lee, W. B. Isaacs, G. Steven Bova, and W. G. Nelson, “CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain reaction: A new prostate cancer biomarker,” Cancer Epidemiology Biomarkers and Prevention, vol. 6, no. 6, pp. 443–450, 1997. View at Google Scholar · View at Scopus
  43. X. Shan, L. Wang, R. Hoffmaster, and W. D. Kruger, “Functional characterization of human methylenetetrahydrofolate reductase in Saccharomyces cerevisiae,” Journal of Biological Chemistry, vol. 274, no. 46, pp. 32613–32618, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. R. A. Waterland, “Assessing the effects of high methionine intake on DNA methylation,” Journal of Nutrition, vol. 136, no. 6, 2006. View at Google Scholar · View at Scopus
  45. A. P. Feinberg, R. Ohlsson, and S. Henikoff, “The epigenetic progenitor origin of human cancer,” Nature Reviews Genetics, vol. 7, no. 1, pp. 21–33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  46. J. J. Tomaszewski, J. L. Cummings, A. V. Parwani et al., “Increased cancer cell proliferation in prostate cancer patients with high levels of serum folate,” Prostate, vol. 71, no. 12, pp. 1287–1293, 2011. View at Publisher · View at Google Scholar · View at Scopus
  47. C. Marchal, M. Redondo, A. Reyes-Engel et al., “Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer,” European Journal of Surgical Oncology, vol. 34, no. 7, pp. 805–810, 2008. View at Publisher · View at Google Scholar · View at Scopus
  48. J. Chen, J. Ma, M. J. Stampfer, C. Palomeque, J. Selhub, and D. J. Hunter, “Linkage disequilibrium between the 677C→t and 1298A→C polymorphisms in human methylenetetrahydrofolate reductase gene and their contributions to risk of colorectal cancer,” Pharmacogenetics, vol. 12, no. 4, pp. 339–342, 2002. View at Publisher · View at Google Scholar · View at Scopus
  49. S. Ogino and R. B. Wilson, “Genotype and haplotype distributions of MTHFR677C→T and 1298A→C single nucleotide polymorphisms: a meta-analysis,” Journal of Human Genetics, vol. 48, no. 1, pp. 1–7, 2003. View at Google Scholar
  50. N. Rosenberg, M. Murata, Y. Ikeda, O. Opare-Sem, E. Geffen, and U. Seligsohn, “The frequent 5, 10-methylenetetrahydrofolate reductase C677T polymorphism is associated with a common haplotype in Whites, Japanese, and Africans,” , American Journal of Human Genetics, vol. 70, no. 3, pp. 758–762, 2002. View at Google Scholar
  51. M. S. Cicek, N. L. Nock, L. Li, D. V. Conti, G. Casey, and J. S. Witte, “Relationship between methylenetetrahydrofolate reductase C677T and A1298C genotypes and haplotypes and prostate cancer risk and aggressiveness,” Cancer Epidemiology, Biomarkers & Prevention, vol. 13, no. 8, pp. 1331–1336, 2004. View at Google Scholar
  52. V. L. Stevens, C. Rodriguez, J. Sun, J. T. Talbot, M. J. Thun, and E. E. Calle, “No association of SNPs in one-carbon metabolism genes with prostate cancer risk,” Cancer Epidemiology, Biomarkers & Prevention, vol. 17, no. 12, pp. 3612–3614, 2008. View at Google Scholar
  53. P. Frost, H. J. Blom, P. Gollete, C. A. Sephhard, and R. G. Matthews, “A candidate genetic risk factor for vascular disease,” Nature Genetics, vol. 10, no. 24, pp. 111–113, 1995. View at Google Scholar
  54. N. M. Van der Put, F. Gabreels, E. M. Stevens et al., “A second common mutation in the methylenetetrahydrofolate reductase gene: an additional risk factor for neural-tube defect?” American Journal of Human Genetics, vol. 62, no. 5, pp. 1044–1051, 1998. View at Google Scholar
  55. J. Summer, D. A. Jencks, S. Khani, and R. G. Matthews, “Photoaffinity labeling of methylnetetrahydrofolate reductase with 8-azido-S-adenosylmethionine,” Journal of Biological Chemistry, vol. 261, no. 17, pp. 7697–7700, 1986. View at Google Scholar
  56. G. Corona, G. Toffoli, M. Fabris et al., “Homocysteine accumulation in human ovarian carcinoma ascetic/cystic fluids possibly caused by metabolic alteration of the methionine cycle in , ovarian carcinoma cells,” European Journal of Cancer, vol. 33, no. 8, pp. 1284–1290, 1997. View at Google Scholar
  57. J. Lin, I. M. Lee, Y. Song et al., “Plasma homocysteine and cysteine and risk of breast cancer in women,” Cancer Research, vol. 70, no. 6, pp. 2397–2405, 2010. View at Publisher · View at Google Scholar
  58. C. M. Ulrich, E. Kampman, J. Bigler et al., “Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?” Cancer Epidemiology, Biomarkers & Prevention, vol. 8, no. 8, pp. 659–668, 1999. View at Google Scholar
  59. H. Refsum, P. M. Ueland, O. Nygard, and S. E. Vollset, “Homocysteine and cardiovascular disease,” Annual Reviews, vol. 49, pp. 31–62, 1998. View at Publisher · View at Google Scholar