Journal of Cancer Epidemiology

Research Article

Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans

Table 2

Folate, vitamins B6, B12, and methionine intake* in total PC, HG, and LG cases and controls.
NutrientControls
𝑛 = 2 7 2 		Total PC
𝑛 = 1 4 4
OR** (95%CI), 𝑃 value		HG PC
𝑛 = 6 8
OR** (95%CI), 𝑃 value		LG PC
𝑛 = 7 7
OR** (95%CI), 𝑃 value
Folate    
 Low/normal (≤700 mcg/day)188 102 54 49
 High (>700 mcg/day)84 42 14 28
   1 . 0 2 ( 9 5 % C I ; 0 . 6 4 - 1 . 6 3 ) 0 . 6 8 ( 9 5 % C I ; 0 . 3 5 - 1 . 3 4 ) 1 . 4 2 ( 9 5 % C I ; 0 . 8 1 - 2 . 4 7 )
   𝑃 = 0 . 9 5 𝑃 = 0 . 2 6 𝑃 = 0 . 2 1
B6    
 Low/normal (≤4.5 mg/day)206 113 57 57
 High (>4.5 mg/day)66 31 11 20
   0 . 9 2 ( 9 5 % C I ; 0 . 5 5 - 1 . 5 4 ) 0 . 6 5 ( 9 5 % C I ; 0 . 3 1 - 1 . 3 3 ) 1 . 2 4 ( 9 5 % C I ; 0 . 6 7 - 2 . 7 )
   𝑃 = 0 . 7 6 𝑃 = 0 . 2 2 𝑃 = 0 . 4 8
B12    
 Low/normal (≤25 mcg/day)209 107 52 56
 High (>25 mcg/day)63 37 16 21
   1 . 2 9 ( 9 5 % C I ; 0 . 7 8 - 2 . 1 2 ) 1 . 1 2 ( 9 5 % C I ; 0 . 5 6 - 2 . 1 6 ) 1 . 3 8 ( 9 5 % C I ; 0 . 7 4 - 2 . 5 )
   𝑃 = 0 . 3 2 𝑃 = 0 . 7 7 𝑃 = 0 . 3 1
Methionine    
 Low/normal (≤2.6 g/day)249 119 60 60
 High (>2.6 g/day)23 25 8 17
   2 . 0 8 ( 9 5 % C I ; 1 . 1 0 - 3 . 9 0 ) 1 . 4 4 ( 9 5 % C I ; 0 . 5 8 - 3 . 5 4 ) 2 . 7 5 ( 9 5 % C I ; 1 . 3 2 - 5 . 7 3 )
   𝑃 = 0 . 0 2 𝑃 = 0 . 4 3 𝑃 = 0 . 0 0 7
*Adjusted for age, race, family history of PC, BMI, and smoking status.
**Referents are subjects in the low intake group of each nutrient of interest.
PC: prostate cancer.
HG PC: high grade (Gleason ≥ 7).
LG PC: low grade (Gleason < 7).