Journal of Cancer Epidemiology

Research Article

Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans

Table 4

ORs and 95%CI for the association between methionine intake and PC risk in carriers and noncarriers of C677T and A1298C MTHFR gene polymorphisms*.
  PC cases 𝑛 = 5 5
Frequency (%)		Controls 𝑛 = 1 9 2
Frequency (%)		OR (95%CI), 𝑃 value
Methionine > 2.6 g/day in
MTHFR polymorphism C677T carriers		   
 CC (homo wild type)36 (65.45)103 (53.65) O R = 1 . 9 6 ( 0 . 5 9 - 6 . 4 1 ) , 𝑃 = 0 . 2 6
 CT (hetero) and TT (homo)19 (34.55)89 (46.35) O R = 2 . 9 3 ( 0 . 7 - 1 2 . 2 4 ) , 𝑃 = 0 . 1 4
Methionine > 2.6 g/day in
MTHFR polymorphism A1298C carriers		   
 AA (homo wild type)36 (65.45)103 (53.37) O R = 0 . 9 7 ( 0 . 2 4 - 3 . 9 2 ) , 𝑃 = 0 . 9 7
 AC (hetero) and CC (homo)19 (34.55)90 (46.63) O R = 6 . 6 7 ( 1 . 5 9 - 2 7 . 8 3 ) , 𝑃 = 0 . 0 1
*Adjusted for age, race, BMI, and smoking status.