Characterization of Pediatric Acute Lymphoblastic Leukemia Survival Patterns by Age at Diagnosis

Table 1

(a) Risk of dying in ALL patients (1973–2009 SEER dataset) by age at diagnosis. (b) Characterization of pediatric ALL clinical features by age group at diagnosis, SEER dataset 1973–2009.

(a)

Age at diagnosis (yr)	Number of patients (%)	Number of deaths (%)	All-cause incidence rate of dying per 1000 person-month	Cancer-specific incidence rate of dying per 1000 person-month
0	452 (3)	229 (51)	8.35	7.47
1	984 (7)	206 (21)	2.07	1.76
2	1968 (14)	250 (13)	1.13	0.93
3	1936 (14)	231 (12)	1.06	0.88
4	1495 (11)	205 (14)	1.28	1.07
5	1025 (7)	168 (16)	1.48	1.23
6	771 (5)	138 (18)	1.74	1.54
7	665 (5)	134 (20)	1.97	1.73
8	541 (4)	108 (20)	1.87	1.63
9	483 (3)	124 (26)	2.84	2.54
10	437 (3)	119 (27)	2.86	2.45
11	444 (3)	120 (27)	3.26	2.80
12	413 (3)	121 (29)	3.29	2.75
13	436 (3)	146 (33)	4.07	3.62
14	445 (3)	140 (31)	3.96	3.17
15	419 (3)	167 (40)	5.44	4.63
16	395 (3)	120 (30)	3.87	3.42
17	321 (2)	129 (40)	5.98	5.38
18	309 (2)	150 (48)	8.19	7.43
19	253 (2)	115 (45)	7.70	7.10

(b)

Variables	Age group at diagnosis (yrs)
	<1 (%)	1–4 (%)	5–9 (%)	10–14 (%)	15–19 (%)
Sex						110.14	<0.0001
Male	217 (48)	3553 (56)	1917 (55)	1273 (59)	1153 (68)
Female	235 (52)	2830 (44)	1568 (45)	902 (42)	544 (32)
Race						54.92	0.05
Caucasian	360 (80)	5353 (84)	2876 (83)	1793 (82)	1435 (85)
AA	44 (10)	373 (6)	255 (7)	208 (10)	125 (7)
Other/unknown	48 (11)	657 (10)	354 (10)	174 (8)	137 (8)
Primary tumor sites						5.85	0.21
1	448 (99)	6313 (99)	3437 (99)	2142 (98)	1668 (98)
≥2	4 (1)	70 (1)	48 (1)	33 (2)	29 (2)
Immunophenotype						375.77	<0.0001
T-cell	13 (3)	223 (3)	376 (11)	306 (14)	233 (14)
B-cell, B-precursor	217 (48)	3389 (53)	1698 (49)	1005 (46)	851 (50)
Radiation						419.28	<0.0001
Yes	61 (14)	785 (12)	574 (17)	616 (29)	462 (27)
No	388 (86)	5569 (88)	2895 (83)	1537 (71)	1219 (73)
Year of diagnosis						44.05	0.027
1973–1977	22 (3)	328 (5)	187 (5)	122 (6)	93 (5)
1978–1982	33 (4)	371 (6)	202 (6)	130 (6)	106 (6)
1983–1987	35 (4)	430 (7)	221 (6)	145 (7)	107 (6)
1988–1992	42 (4)	552 (9)	303 (9)	151 (7)	110 (6)
1993–1997	53 (3)	852 (13)	438 (13)	244 (11)	172 (10)
1998–2002	99 (3)	1357 (21)	782 (22)	476 (22)	381 (22)
2003–2007	126 (3)	1790 (28)	943 (27)	638 (29)	522 (31)
2008-2009	42 (3)	703 (11)	409 (12)	269 (12)	206 (12)
Survival time (months)
75th percentile	11	—	164	44	22
Median	40	—	—	—	289
Mean (SE)	198 (11.26)	364 (2.47)	335 (3.80)	282 (5.51)	233 (6.55)
Five-year interval Survival (months)
0–60	46	87	83	71	57
61–120	43	83	77	65	53
Mortality status
Dead	229 (51)	892 (14)	672 (19)	646 (30)	681 (40)	871.65	<0.0001
Alive	223 (49)	5491 (86)	2813 (81)	1529 (70)	1016 (60)