Journal of Cancer Epidemiology / 2014 / Article / Tab 3

Research Article

Characterization of Pediatric Acute Lymphoblastic Leukemia Survival Patterns by Age at Diagnosis

Table 3

Hazard risk of mortality associated with age at diagnosis in pediatric ALL patients (1973–2009 SEER dataset) in an adjusted multivariable Cox proportional hazard model, stratified by the year of diagnosis.

VariableModel without immunophenotypeModel with immunophenotype
Adjusted hazard ratio (AHR)95% C.I.Adjusted hazard ratio (AHR)95% C.I.

Age at diagnosis (yr)
 <11Reference1Reference
 1–40.180.15, 0.20<0.00010.130.10, 0.16<0.0001
 5–90.250.22, 0.29<0.00010.200.16, 0.26<0.0001
 10–140.430.37, 0.50<0.00010.370.29, 0.46<0.0001
 15–190.680.59, 0.79<0.00010.600.48, 0.75<0.0001
Sex
 Female1Reference1Reference
 Male1.251.16, 1.34<0.00011.231.09, 1.380.0004
Race
 Caucasian1Reference1Reference
 AA1.441.27, 1.62<0.00011.331.10, 1.610.003
Primary tumor sites
 11Reference1Reference
 ≥20.860.67, 1.110.251.450.94, 2.230.09
Radiation
 No1Reference1Reference
 Yes0.940.87, 1.030.151.020.89, 1.180.77
Immunophenotype
 T-cell1Reference
 B-cell, B-precursor0.840.73, 0.960.01

C.I.: confidence interval.

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