Journal of Cancer Epidemiology / 2015 / Article / Tab 2

Research Article

Increase in Distant Stage Breast Cancer Incidence Rates in US Women Aged 25–49 Years, 2000–2011: The Stage Migration Hypothesis

Table 2

Trend in age-standardized incidence rate for women aged 25–49 years with invasive breast cancer in SEER registries, by estrogen (ER) and progesterone (PR) hormone-receptor status category: annual percent change (APC) by stage at diagnosisa,b.

Stage 2000 20112000–2011
NumberRate (CL)NumberRate (CL)APC, % (CL)

ER negative/PR negative
Distant1240.8 (0.7, 1.0)1781.2 (1.0, 1.4)4.7 (2.4, 7.0)*
Regional11778.0 (7.6, 8.5)9686.6 (6.2, 7.1)−1.6 (−2.9, −2.0)*
 IIICb1651.1 (1.0, 1.3)970.7 (0.5, 0.8)−3.6 (−5.2, −2.1)*
Localized13909.5 (9.0, 10.0)13809.3 (8.9, 9.9)−0.3 (−1.6, +1.0)

ER positive/PR negative
Distant370.3 (0.2, 0.3)860.6 (0.5, 0.7)8.0 (5.5, 10.5)*
Regional3732.5 (2.3, 2.8)4443.1 (2.8, 3.4)0.8 (−0.5, +2.2)
 IIICb470.3 (0.2, 0.4)370.3 (0.2, 0.4)−2.4 (−4.4, −0.3)*
Localized4142.8 (2.6, 3.1)5373.6 (3.3, 3.9)2.6 (1.6, 3.6)*

ER positive/PR positive
Distant1471.0 (0.8, 1.2)3612.5 (2.2, 2.7)9.0 (7.6, 10.4)*
Regional238716.3 (15.7, 17.0)301420.5 (19.8, 21.2)2.3 (1.8, 2.8)*
 IIICb2211.5 (1.3, 1.7)2121.4 (1.2, 1.6)−1.0 (−2.6, +0.6)
Localized305220.9 (20.2, 21.7)456730.8 (29.9, 31.7)4.0 (3.1, 4.8)*

aSummary stage 2000 (1988+) [7] (see text).
bSEER breast-adjusted AJCC 6th edition stage IIIC, within regional summary stage cancers [11] (see text and Table 1).
CL: confidence limits (95%), lower and upper, on rate or on APC.
SEER: Surveillance, Epidemiology, and End Results Program of the National Cancer Institute.
*CL do not include zero.