Review Article

Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors

Table 1

Summary of number of reports by risk factor and global methylation measure.

FactorsTotal # of reportsLINE-1Alu5-mdC

Demographic Factors
 Age312164
 Sex221741
 Race/ethnicity6501
 Education7601
Lifestyle factors
 Physical activity5500
 Alcohol171331
 Smoking221642
Dietary factors
 BMI171331
 Vegetables111100
 Fruit6600
 Folate131201
Reproductive factors
 Menopause status2101
 Fetal birthweight1100
 Family history of breast cancer6411
 Age at menarche1001
 Age at first birth1001
 Parity1001
 Hormones4301