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E-Journal of Chemistry
Volume 1 (2004), Issue 5, Pages 272-275

Synthesis of Novel Schiff Base and Azetidinone Derivatives and their Antibacterial Activity

Kamal Vashi and H. B. Naik

Department of Chemistry, Veer Narmad South Gujarat University, Surat 395007, India

Received 20 September 2004; Accepted 10 October 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of Compound 4-(2᾽-hydroxy-3᾽-chloro-5᾽-ethyl phen-1᾽-yl)-1-(4᾽-tolyl)-3-chloro-2-azetidinone 4a-j have been prepared by the reaction of 2 -hydroxy-3 -chloro-5 -ethyl-N-(p-tolyl)-chalconimines 3a-j with chloroacetyl chloride in the presence of triethylamine. The Schiff base derivatives 3a-j has been prepared by the condensation of different substituted chalone derivatives 1 with p-toluidine 2. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus and Escherichia coli.