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E-Journal of Chemistry
Volume 1, Issue 3, Pages 170-177
http://dx.doi.org/10.1155/2004/648376

2D-QSAR Analysis of Oxadiazole Substituted α-Isopropoxy phenylpropionic Acids as PPAR-α & PPAR-λ Agonists

Soni L. K., Gupta A. K., and Kaskhedikar S. G.

Department of Pharmacy, S.G.S.I.T.S., 23 Park Road, Indore-452003, India

Received 22 March 2004; Accepted 1 May 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A quantitative structure activity relationship study on a series of oxadiazole substituted α-isopropoxy phenylpropionic acids with activity on PPAR-α and PPAR-λ was made using combination of various physiochemical descriptors. Several statistical regression expressions were obtained using stepwise multiple linear regression analysis. The best quantitative structure activity relationship model was further validated by leave one out cross validation method. Steric parameter (molar refractivity) was found to have significant correlationship with PPAR-λ agonist activity and hydrophobic (Hansch substituent constant), electronic parameter (field effect) were found to have significant correlationship with PPAR-α agonist activity. The increment in the number of carbon atom (indicative variable) between the oxadiazole tail and central phenoxy moiety increases the PPAR-λ agonist activity whereas decreases the PPAR-α agonist activity