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E-Journal of Chemistry
Volume 1, Issue 1, Pages 17-31
http://dx.doi.org/10.1155/2004/671567

Synthesis and QSAR Study of Some HDL Cholesterol Increasing Quinazolinone Derivatives

M. B. Deshmukh and Savita Dhongade (Desai)

Department of Chemistry, Shivaji University, Kolhapur-416004, India

Received 13 February 2004; Accepted 24 February 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We describe here an easy and efficient method to obtain S-alkylated derivatives of thio-quinazolinone using different alkylating agents via a solvent-free microwave-assisted method. The alkylated thio quinazolinones were further sequentially condensed with hydrazine hydrate and different aromatic aldehydes to get the hydrazones, which were studied for QSAR. The synthesized compounds were subjected to a prediction of biological activities. A software application (PASS) was used for this purpose. The relationship between structure and different biological activities was studied and the different derivatives were recommended for the screening of some specific activities like anti-tuberculosic, anti-mycobacterial and HDL cholesterol increasing activities.