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E-Journal of Chemistry
Volume 1 (2004), Issue 2, Pages 93-98
http://dx.doi.org/10.1155/2004/732420

Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group

H. S. Patel, H. D. Desai, and H. J. Mistry

Department of Chemistry, S.P. UniversityV.V. Nagar -388 120, Gujarat, India

Received 3 March 2004; Accepted 20 March 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Novel N-substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4-sulfonyloxy aniline (SA) derivatives (2a-h) have been prepared by the condensation reaction of N-Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N-Chloroacetyl) derivatives (3a-h). These derivatives are then reacted with N-phenyl piperazine to yield the corresponding piperazine derivatives (4a-h).