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E-Journal of Chemistry
Volume 2 (2005), Issue 2, Pages 109-112

Synthesis and Antibacterial Activity of Chalcones and Pyrimidine-2-ones

A. K. Parekh and K. K. Desai

Department of chemistry, Veer Narmad South Gujarat University, Surat-395007, India

Received 27 December 2004; Accepted 9 March 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Some new chalcones have been prepared by Claisen-schmidt condensation of ketone and different aromatic aldehydes. These chalcones on condensation with urea in presence of acid gave Pyrimidine-2-ones. The synthesized compounds have been characterized by elemental analysis, IR and 1H NMR spectral data. They have been screened for their antibacterial activity against Gram positive bacteria B. subtillis & S. aureus and Gram negative bacteria E. coli & S. typhi.