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E-Journal of Chemistry
Volume 2, Issue 4, Pages 228-230

One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Catalyzed by Chlorosulfonic Acid

Jin Tong-Shou, Zhao Ying, Liu Li-Bin, and Li Tong-Shuang

College of Chemistry and Environmental Science, Hebei University, Hebei Province, Baoding 071002, China

Received 22 July 2005; Accepted 28 August 2005

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient synthesis of 3,4-dihydropyrimidin-2-ones (DHPMs) from the aldehydes, β-ketoesters and urea in ethanol using chlorosulfonic acid as the catalyst is described. Compared with the classical Biginelli reaction conditions, this method has the advantage of excellent yields and short reaction time.