Journal of Chemistry

Journal of Chemistry / 2005 / Article

Open Access

Volume 2 |Article ID 690296 | https://doi.org/10.1155/2005/690296

Ketan Mistry, K. R. Desai, "Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity", Journal of Chemistry, vol. 2, Article ID 690296, 5 pages, 2005. https://doi.org/10.1155/2005/690296

Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity

Received15 Feb 2005
Accepted25 Mar 2005

Abstract

Pyrimidine-2-one derivatives, 2-[2-{1ʹ-(p-nitrophenyl)-6ʹ-(substituted-phenyl)-pyrimidine-2ʹ-one-4ʹ-yl}-hydrazinomethyl]-3-(p-methoxy phenyl)-quina-zoline-4(3H)-one [4a-j] have been synthesised by the condensation of p-nitro phenylurea and various chalcones, 2-(substituted phenylchalconylhydrazinomethyl)-3-(p-methoxyphenyl)-quinazoline-4(3H)-one [3a-j] in the presence of catalytic amount of conc. HCl. And this series of chalcones have been synthesised by the reaction of 2-acetylhydrazinomethyl-3-(substitutedphenyl)-quinazoline-4(3H)-one [2] with different substituted aldehydes in presence of a 2% NaOH solution. These products have been characterized by means of elemental analysis, IR and NMR spectrul studies and tested for antibacterial activities against Staphylococcus aureus, Bacillus subtillis, Escherichia coli and Salmonella typhi.

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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