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E-Journal of Chemistry
Volume 3 (2006), Issue 1, Pages 9-12
http://dx.doi.org/10.1155/2006/643624

Spectrophotometric Determination of Ziprasidone in Pharmaceutical Formulations

G. Srinubabu, B. Sudha Rani, and J. V. L. N. Seshagiri Rao

University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam–530003, (A.P.), India

Received 10 September 2005; Accepted 23 January 2006

Copyright © 2006 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple and reproducible spectrophotometric method has been developed for the determination of Ziprasidone hydrochloride monohydrate (ZPS) in bulk and in dosage forms. The method is based on the extraction of the drugs into organic layer of the dye TPooo in presence of 0.1 N hydrochloric acid and the absorbances were measured at 490 nm. Results indicate that the proposed method was simple, sensitive, accurate and reproducible.