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E-Journal of Chemistry
Volume 4, Issue 2, Pages 166-172
http://dx.doi.org/10.1155/2007/503952

Synthesis and Antibiotic Activity of Mebendazole Derivatives of Pharmacological Interest

Kavita Rathore, Usha Ameta, Swati Ojha, Ranjana Sharma, and G. L. Talesara

Synthetic Organic Chemistry Laboratory, Deptt. of Chemistry, M. L. Sukhadia University, Udaipur-313001, India

Received 20 October 2006; Accepted 15 November 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Mebendazole is a well known anti-helimintic and belongs to the benzimidazole group of medicines. In order to achieve better medicinal results, i.e. enhanced activity and low toxicity, structural modifications are made in the existing drugs. Some 5-benzoyl-N-[1-(alkoxyphthalimido) benzimidazol-2-yl] carbamic acid methyl ester (3a-c) and 5-benzoyl-N-[1-(2,3-bis oxyphthalimido∕oxysuccinimido propyl benzimidazol-2-yl) carbamic acid methyl ester (7a-b) have been synthesized from two different routes. Structures of the compounds have been established on the basis of elemental analysis and spectral studies. All the synthesized compounds (3a-c) and (7a-b) were assayed in vitro for antimicrobial activity against mebendazole (itself) and standard [ciprofloxacin (antibacterial) and fluconazole (antifungal)].