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E-Journal of Chemistry
Volume 4, Issue 1, Pages 60-66
http://dx.doi.org/10.1155/2007/507590

Studies on Synthesis of Pyrimidine Derivatives and their Pharmacological Evaluation

T. A. Naik and K. H. Chikhalia

Department of chemistry, Veer Narmad South Gujarat University, Surat-395 007, Gujarat, India

Received 14 August 2006; Accepted 3 October 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

1,3,4-Oxadiazoles were associated with broad spectrum of biological activities including antituberculosis, anticonvulsant, anti-inflammatory, insecticidal, antifungal, analgesic and antitumor properties. Morpholine derivatives find their wide spectrum of antimicrobial activity and exhibit anthelmintic, bactericidal and insecticidal activity. Pyrimidine derivatives are also reported to possess antibacterial, antimicrobial, antifungal, anticancer and anticonvulsant activities. Encouraged by this observations we decided to synthesised novel pyrimidine derivatives.