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E-Journal of Chemistry
Volume 4, Issue 1, Pages 32-38
http://dx.doi.org/10.1155/2007/639828

Synthesis, Characterization and Antimicrobial Activity of Methylquinolino[3,2-b][1,5]benzodiazepine and Methylquinolino[3,2-b][1,5]benzoxazepine and its Various Metal Complexes

B. Basavaraju,1 H. S. Bhojya Naik,2 and M. C. Prabhakara2

1Department of Biotechnology, GM Institute of Technology, Davangere-577 006, Karnataka, India
2Department of PG studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta-577 451, Shimoga, Karnataka, India

Received 3 July 2006; Accepted 8 September 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

2-Chloro-6-methylquinoline-3-carbaldehyde was condensed with o-Phenylenediammine and 2-aminophenol in presence of potassium iodide. The resulting Methylquinolino[3,2-b][1,5]benzodiazepine (MQBD) and Methylquinolino[3,2-b][1,5]benzoxazepine(MQBO) were characterized by elemental analysis and spectral studies. The metal chelates viz Pd(II), Rh(III) and Ru(III) of ligands were prepared and characterized by metal-ligand (M:L) ratio, UV-Visible, IR, 1H NMR spectroscopes and magnetic properties. The antibacterial and antifungal activity of MQBD, MQBO and its metal complexes were screened against various bacteria and fungi. The results show that all these samples are good antimicrobial agents.