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E-Journal of Chemistry
Volume 4, Issue 4, Pages 563-573

In vitro Evaluation of Some Different Brands of Alprazolam Tablets

A. Ashnagar, M. Kouchak, M. Soltani, and A. Salimi

School of Pharmacy, Ahwaz Jundi Shapour Univ. of Medical Sciences, Ahwaz, Iran

Received 9 May 2007; Accepted 30 June 2007

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Alprazolam belongs to a group of medicines called benzodiazepines. These medicines are thought to work by their action on brain chemicals. Alprazolam has sedative effects and is used to treat: (i) Anxiety and (ii) Panic attacks. The results obtained in this research by various HPLC analyses and other physicochemical tests have shown that alprazolam tablets manufactured by Dr. Abidi and Poursina Pharmaceutical Companies of Iran have the standard limits acceptable by the internationally well known Pharmacopoeia such as USP and can satisfy the needs of patients quite well and are quite comparable with Xanax® of USA and Apo-Alpraz® of Canada.