Journal of Chemistry

Journal of Chemistry / 2008 / Article

Open Access

Volume 5 |Article ID 125917 | https://doi.org/10.1155/2008/125917

K. Prakash, P. Narayana Raju, K. Shanta Kumari, M. Lakshmi Narasu, "Solubility and Dissolution Rate Determination of Different Antiretroviral Drugs in Different pH Media Using UV Visible Spectrophotometer", Journal of Chemistry, vol. 5, Article ID 125917, 6 pages, 2008. https://doi.org/10.1155/2008/125917

Solubility and Dissolution Rate Determination of Different Antiretroviral Drugs in Different pH Media Using UV Visible Spectrophotometer

Received18 Dec 2007
Revised10 Mar 2008
Accepted05 Jun 2008

Abstract

Solubility and dissolution rate of three antiretroviral drugs such as lamivudine, zidovudine and stavudine was studied in four media having different pH. The samples were analyzed by using UV Visible spectrophotometer. lamivudine shows more solubility that is 276.08 mg/mL in 0.01 N HCl. Stavudine showing highest solubility that is 101.23 mg/mL in pH 4.5 acetate buffer. Zidovudine showing highest solubility that is 28.90 mg/mL in both water and 0.01 N HCl. All three drugs showing lower solubility in pH 6.8 phosphate buffer. Lamivudine and stavudine showing good dissolution rate in all media and showing similar release profiles and good correlation, whereas in zidovudine it was clearly observed a slower release at initial time points and then faster release profiles. The solubility and dissolution data in various media is helpful in predicting the bioavailability and also in dissolution method development.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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