Journal of Chemistry

Journal of Chemistry / 2008 / Article

Open Access

Volume 5 |Article ID 161783 |

Rajiv Dahiya, Anil Kumar, "Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives", Journal of Chemistry, vol. 5, Article ID 161783, 11 pages, 2008.

Synthesis, Spectral and Anthelmintic Activity Studies on Some Novel Imidazole Derivatives

Received02 Apr 2008
Revised08 Jun 2008
Accepted24 Jun 2008


Present study describes the synthesis of a novel series of 3,5-diiodo-4-(5-nitro-1H-2-imidazolyl)benzoyl amino acids and di/tri/tetrapeptides using diisopropylcarbodiimide/dicyclohexylcarbodiimide (DIPC/DCC) as coupling agents and N-methylmorpholine/triethylamine (NMM/TEA) as bases. Structure elucidation of all the newly synthesized compounds was done by elemental analysis and IR, 1H NMR, 13C NMR and mass spectral data. Synthesized imidazolopeptides were screened for their anthelmintic activity and found to possess moderate to good bioactivity against earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus eugeniea when compared to reference drugs - albendazole and mebendazole at dose level of 2 mg mL−1.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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