Pradeep Yadav, Y. C. Joshi, "Synthesis and Spectral Study of Novel Norfloxacin Derivatives", Journal of Chemistry, vol. 5, Article ID 357073, 5 pages, 2008. https://doi.org/10.1155/2008/357073
Synthesis and Spectral Study of Novel Norfloxacin Derivatives
Reaction of [1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-quinolone-3-carboxylic acid (norfloxacin) with thiazole / benzothiazole diazonium chloride to get new piperazine substituted norfloxacin derivative. These norfloxacin derivatives were further condensed with various β-diketone to get novel acid derivatives of 1-Ethyl-6-fluoro-4-oxo-7- [4 (thiazol-2-yldiazenyl)-piperzin-1-yl]-1,4-dihydro-quinoline-3-carboxylic acid (6a-e) and 7-(4-(benzo[d]thiazol-2-yldiazenyl)piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid (6 f-j). Structures of these compounds were established on the basis of spectral studies viz. IR, 1H NMR etc.
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