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E-Journal of Chemistry
Volume 5 (2008), Issue 2, Pages 347-354
http://dx.doi.org/10.1155/2008/394737

Syntheses of 1, 2, 4 Triazole Derivatives and their Biological Activity

Freddy H. Havaldar and Abhay R. Patil

Nadkarny-Sacasa Research Laboratory, Department of Chemistry, St. Xavier's College, Mumbai - 400 001, India

Received 14 October 2007; Accepted 10 December 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cyclisation of [4-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-phenoxy]-acetic acid-N'-(substituted phenyl)-thiosemicarbazides with sodium metal in 99.0 % ethanol gave 3-[4-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4 triazol-3-ylmethoxy)- phenyl]-2-phenyl-3H-quinazolin-4-one . The structures of the newly synthesized compounds have confirmed by IR, 1H NMR and Mass spectra. The compounds have also been screened for their biological activity.