Journal of Chemistry

Journal of Chemistry / 2008 / Article

Open Access

Volume 5 |Article ID 415030 | https://doi.org/10.1155/2008/415030

K. R. Kishore Kumar Reddy, G. Syam Prasad, M. Anil Kumar, C. Suresh Reddy, C. Naga Raju, "Synthesis and Biological Activity of Some new 2-Heterocyclic/acyclic amino/4'-acetamidophenoxy-3-(4-chloro-phenyl)-3, 4-dihydrobenzo[e]- [1,3,2]oxazaphosphinine 2-sulfides", Journal of Chemistry, vol. 5, Article ID 415030, 8 pages, 2008. https://doi.org/10.1155/2008/415030

Synthesis and Biological Activity of Some new 2-Heterocyclic/acyclic amino/4'-acetamidophenoxy-3-(4-chloro-phenyl)-3, 4-dihydrobenzo[e]- [1,3,2]oxazaphosphinine 2-sulfides

Received01 Sep 2007
Accepted01 Nov 2007

Abstract

2-Heterocyclic/acyclicamino/4'-acetamidophenoxy-3-(4-chlorophenyl)-3,4-dihydrobenzo-[e][1,3,2]oxazaphosphinine 2-sulfides (4a-j) were synthesized through a two steps process. In the first step, 2-chloro-3-(4-chlorophenyl)-3, 4-dihydrobenzo[e] [1,3,2]-oxazaphosphinine 2-sulfide (2) was prepared by the reaction of 2-[(4-chlorophenylamino)methyl]phenol (1) with thiophosphoryl chloride in the presence of triethylamine in dry toluene-tetrahydrofuran. In the second step, 2 was treated with various heterocyclic/acyclicamines/4'-acetamidophenol in presence of triethylamine-/ sodium hydride in toluene-tetrahydrofuran at 45-50°C . All the synthesized compounds (4a-j) were characterized by elemental analysis, IR, NMR(1H, 13C and 31P) and mass spectra and their biological activity was evaluated for antimicrobial activity.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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