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E-Journal of Chemistry
Volume 5, Issue 4, Pages 679-687

A Convenient Synthesis and Antibacterial Activity of Novel α-Aminophosphonic Acid Esters from Amino Acids/Esters (Kabachnik-Fields Reaction)

CH. Mohan,1 B. Hari Babu,1 C. Naga Raju,1 and R. Usha Nagalakshmi2

1Department of Chemistry, Sri Venkateswara University, Tirupati-517 502, India
2Department of Botany, Sri Venkateswara University, Tirupati-517 502, India

Received 30 September 2007; Accepted 20 November 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of novel α-aminophosphonic acid esters (5a-n) were achieved with high yields through one-pot three component reaction process by Kabachnik-Fields reaction. It involves the reaction among amino acids/esters, substituted aromatic aldehydes and dialkyl phosphites in absolute ethanol at reflux temperature. Their structures were established by elemental analysis IR, ¹H, ¹³C, ³¹P NMR and mass spectral data. All the title compounds were screened for their antibacterial activity. Most of the compounds exhibited moderate antimicrobial activity.