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E-Journal of Chemistry
Volume 6, Issue 1, Pages 177-182

Synthesis, Characterization and Biological Activities of 3,5-Diaryltetrahydro-N-[(phenylamino)methyl]-1,4-thiazine-1,1-dioxide

V. Sundari,1 G. Nagarajan,1 S. Gurumurthy,1 and R. Valliappan2

1Chemistry Division, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar-608 002, India
2Chemistry Wing, DDE, Annamalai University, Annamalai Nagar-608 002, India

Received 13 August 2008; Revised 14 September 2008; Accepted 18 September 2008

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Synthesis of 3,5-diaryltetrahydro-N- [(4’-nitroanilino)methyl-thiazine-1,1-dioxide and N-[(4’-methylanilino)methyl-]-1,4-thiazine-1,1-dioxides by condensing 3,5-diaryl-tetrahydro-1,4-thiazine-1,1-dioxide with formaldehyde and 4-nitroaniline/4-methylaniline in the presence of hydrochloric acid is reported. The structures of the synthesized compounds have been confirmed by elemental and spectral analysis. The preliminary screening of the compounds for their biological activities gives significant results