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E-Journal of Chemistry
Volume 6 (2009), Issue 3, Pages 725-728
http://dx.doi.org/10.1155/2009/294794

Protective Effect of Dodonaea viscosa (L) Against Lead Acetate Induced Altered Glycoprotein Profiles in Rats

D. Sivanesan,1 A. V. Veera Thamarai Selvi,1 R. Bhakyaraj,2 and T. Arunachalam3

1Department of Biochemistry, J.J. College of Arts and Science, Pudukkottai-622 404, Tamil Nadu, India
2PG and Research Department of Microbiology, J.J. College of Arts and Science, Pudukkottai-622 404, Tamil Nadu, India
3Department of Chemistry, J.J. College of Arts and Science, Pudukkottai-622 404, Tamil Nadu, India

Received 2 October 2008; Revised 8 December 2008; Accepted 1 January 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The present study was undertaken to examine the inhibitory effect of crude leaves of Dodonaea viscosa (L) on lead acetate induced synthesis of glycoproteins and sialic acid in liver and plasma. Enhanced synthesis of glycoproteins (protein - bound hexose and protein - bound hexosamine) and sialic acid levels were found in liver and plasma of the lead acetate poisoned rats. Administration of crude leaves of D.viscosa (100 mg/100 g body weight P.O.) effectively suppressed the synthesis of glycoproteins and sialic acid in liver and thereby controlling the concentration in plasma. The results suggest that D.viscosa may exert its membrane protection effect by inhibiting the synthesis of glycoproteins and sialic acid induced by lead acetate.