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E-Journal of Chemistry
Volume 6, S1, Pages S53-S58
http://dx.doi.org/10.1155/2009/353268

Synthesis of Multi-substituted 4,5-Dihydrofuran Derivatives from (S)-Limonene and 1,3-Dicarbonyl Compounds and their Biological Activities

E. Findik,1 A. Dingil,1 I. Karaman,2 Y. Budak,1 and M. Ceylan1

1Department of Chemistry, Faculty of Arts and Sciences, Gaziosmanpasa University-60250, Tokat, Turkey
2Department of Biology, Faculty of Arts and Sciences, Gaziosmanpasa University-60250, Tokat, Turkey

Received 23 December 2008; Accepted 20 February 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Multi-substituted 4,5-dihydrofuran derivatives were regioselectively synthesized by the reaction of α-carbo radical produced from 1,3-dicarbonyl compounds by oxidation with Mn(OAc)3 in Acetic acid and S-(-)-limonene. All the compounds were tested for their antibacterial and antifungal activities by the disc-diffusion technique.