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E-Journal of Chemistry
Volume 6 (2009), S1, Pages S183-S188
http://dx.doi.org/10.1155/2009/361564

Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives

S. B. jadhav, R. A. shastri, K. V. gaikwad, and S. V. gaikwad

P. G. Department of Chemistry, Milind College of Science, Aurangabad-431001, Maharashtra, India

Received 5 April 2009; Accepted 1 June 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A new series of 1H-3-(4’-substituted phenyl)-5-(6’’-methoxy napthaline)-2-pyrazolines (4a-e) and 1H-3-(4’-substituted phenyl)-5-(6’’-methoxynapthaline)-2-isoxazolines (5a-e) were synthesized by reacting 1-(4’-substituted phenyl)-3-(6’’-methoxynapthaline)-2-propene-1-one (3a-e) with hydrazine hydrate and hydroxylamine hydrochloride respectively. All these compounds were characterized by means of their IR, 1H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.