Synthesis and Antimicrobial Studies of Some Novel Pyrazoline and Isoxazoline Derivatives

Abstract

A new series of 1H-3-(4’-substituted phenyl)-5-(6’’-methoxy napthaline)-2-pyrazolines (4a-e) and 1H-3-(4’-substituted phenyl)-5-(6’’-methoxynapthaline)-2-isoxazolines (5a-e) were synthesized by reacting 1-(4’-substituted phenyl)-3-(6’’-methoxynapthaline)-2-propene-1-one (3a-e) with hydrazine hydrate and hydroxylamine hydrochloride respectively. All these compounds were characterized by means of their IR, ¹H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds exhibited significant to moderate antimicrobial activity.