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T. Surendiran, S. Balasubramanian, Sivaraj D., "Microwave Assisted Synthesis of Novel 1,2,3,4-Tetrahydrocarbazolyl thiazolidin-4-ones and Azetidin-2-ones and its Biological Behavior", Journal of Chemistry, vol. 6, Article ID 424172, 7 pages, 2009. https://doi.org/10.1155/2009/424172
Microwave Assisted Synthesis of Novel 1,2,3,4-Tetrahydrocarbazolyl thiazolidin-4-ones and Azetidin-2-ones and its Biological Behavior
Abstract
A new family of 1,2,3,4 – tetrahydrocarbazolyl thiazolidin-4-ones (4a-e) and 1,2,3,4–tetrahydrocarbazolyl azetidin-2-ones (5a-e) were individually derived using N-[(α-substituted bezylidenehydrazino) acetyl] -1,2,3,4-tetra-hydrocarbazoles 3a-e by cyclization with thioglycolic acid and chloro- acetylchloride respectively. The compounds (3a-e) were prepared by condensation of N-(hydrazinoacetyl) 1,2,3,4-tetrahydrocarbazole (2) with a series of aldehydes. The compound 2 was obtained by the hydrazinolysis of N-(chloroacetyl)-1,2,3,4-tetrahydrocarbazole (1). These products were characterized by IR, NMR, MASS spectra and by elemental analysis. All the titled compounds (4a-e) and 5(a-e) were screened for antibacterial and antifungal activities.
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Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
