Table of Contents Author Guidelines Submit a Manuscript
E-Journal of Chemistry
Volume 6, S1, Pages S374-S380

Microwave Assisted Synthesis of Novel 1,2,3,4-Tetrahydrocarbazolyl thiazolidin-4-ones and Azetidin-2-ones and its Biological Behavior

T. Surendiran,1,2 S. Balasubramanian,3 and Sivaraj D.4

1Research Department of Chemistry, Sathyabama University, Jeppiaar Nagar, Chennai, India
2Department of Chemistry, Diredawa University, Diredawa, Ethiopia
3Research Department of Chemistry, Mohamed Sathak A.J.College of Engineering, Chennai, India
4Emirates Environmental Protection Company (EPO), Dubai, UAE

Received 11 January 2009; Accepted 6 March 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new family of 1,2,3,4 – tetrahydrocarbazolyl thiazolidin-4-ones (4a-e) and 1,2,3,4–tetrahydrocarbazolyl azetidin-2-ones (5a-e) were individually derived using N-[(α-substituted bezylidenehydrazino) acetyl] -1,2,3,4-tetra-hydrocarbazoles 3a-e by cyclization with thioglycolic acid and chloro- acetylchloride respectively. The compounds (3a-e) were prepared by condensation of N-(hydrazinoacetyl) 1,2,3,4-tetrahydrocarbazole (2) with a series of aldehydes. The compound 2 was obtained by the hydrazinolysis of N-(chloroacetyl)-1,2,3,4-tetrahydrocarbazole (1). These products were characterized by IR, NMR, MASS spectra and by elemental analysis. All the titled compounds (4a-e) and 5(a-e) were screened for antibacterial and antifungal activities.