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E-Journal of Chemistry
Volume 6, S1, Pages S163-S170
http://dx.doi.org/10.1155/2009/451967

A Sensitive UV Spectrophotometric Method for the Determination of Gabapentin

R. Singh Gujral, S. Manirul Haque, and P. Shanker

Vardhman Chemtech Ltd, Nimbua, Dera Bassi, Mohali (Punjab), India

Received 1 April 2009; Accepted 5 June 2009

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

An accurate and validated spectrophotometric method was developed for the determination of gabapentin. This is simple, sensitive and low cost UV spectrophotometric method. The method is based on the direct measurement of the native absorbance of the drug. The detection was done at 210 nm. The method was linear in the range of 0.25 - 3.5 µ g/mL with correlation coefficient of 0.9999. It is validated according to the ICH guidelines with respect to linearity, selectivity, accuracy and precision, limit of quantitation and limit of detection. The method has been applied to assess gabapentin in pharmaceutical formulations with good accuracy and precision and relatively free of interference from coexisting substances.